Metoject

$55.80$61.31

Methotrexate works by inhibiting the metabolism of folic acid, which is necessary for cell replication and growth. Its immunosuppressive and anti-inflammatory effects help manage severe symptoms in various autoimmune conditions without significant steroidal side effects.

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Description

Metoject, a formulation of methotrexate, is primarily used in managing autoimmune diseases such as rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis. It acts as a disease-modifying antirheumatic drug (DMARD). Methotrexate interferes with the growth of certain body cells, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells

Additional information

Usage:

Indications:

● Management of rheumatoid arthritis
● Treatment of severe psoriasis not responsive to other treatments
● Management of juvenile idiopathic arthritis

Patients Should:

● Adhere strictly to the prescribed dosage to manage symptoms effectively.
● Be aware of potential liver toxicity and monitor liver function regularly.
● Avoid alcohol consumption to prevent increased risk of liver damage.
● Consult healthcare providers if pregnant, since methotrexate can cause birth defects.
● Report any side effects such as sore throat, fever, or unusual bruising to their healthcare provider immediately.

Administration

Forms:

● Injectable solution for subcutaneous injection, typically administered once per week.
● Precautions
● Contraindicated in patients with liver disease, alcoholism, or compromised immune systems.
● Regular monitoring of kidney function, liver enzymes, and blood cell counts are critical.
● Use cautiously in patients with pre-existing hematological disorders.

Drug Interactions

● Methotrexate may interact with nonsteroidal anti-inflammatory drugs (NSAIDs), certain antibiotics, and live vaccines.
● Concurrent use with other hepatotoxic drugs can increase liver damage risks.

Side Effects

● Nausea
● Fatigue
● Mouth ulcers
● Hair thinning

Severe side effects requiring immediate attention:

● Pulmonary symptoms (e.g., persistent cough, shortness of breath)
● Liver toxicity (e.g., yellowing of the skin or eyes, abdominal pain)
● Severe renal impairment
● Blood dyscrasias (e.g., leukopenia, thrombocytopenia)

Storage

● Store the injectable solution in a refrigerator, protected from light.

Special Precautions

● Prior to initiating therapy, it is essential to confirm the absence of latent infections or active tuberculosis.
● Patients must avoid conception (both male and female), as methotrexate can cause genetic defects.
● Regular screening for respiratory function and liver biopsy may be necessary for long-term users.

Overdose

● Overdose symptoms can include severe gastrointestinal toxicity, bone marrow suppression, and acute renal failure. Immediate medical attention is crucial.

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