Indications:
● Orthostatic Hypotension: Midodrine is indicated for the treatment of symptomatic orthostatic hypotension, which can result from various conditions, including dysautonomia, multiple system atrophy, and other forms of autonomic dysfunction. It is not used for other types of low blood pressure that occur while sitting or lying down.
Patient Guidelines
Patients prescribed Midodrine should adhere to the following guidelines:
● It's crucial to follow dosing schedules strictly, as inappropriate use can lead to significant blood pressure increases, especially in a prone position.
● Monitor blood pressure regularly, especially in a supine position, to avoid potential complications from excessive blood pressure increases.
● Patients should be mindful of the last dose of the day, timing it to avoid the supine hypertension that can occur during sleep.
● Inform healthcare providers of all existing medical conditions, particularly cardiovascular or kidney diseases, which may influence drug suitability.
● Disclose all current medications to healthcare professionals to mitigate the risk of adverse interactions with Midodrine.
Administration Details
● Formulation: Midodrine is available in oral tablet form.
● Dosage: The typical initial dosage might be 2.5mg to 10mg, taken three times daily, with adjustments made based on the patient's response and blood pressure measurements.
Safety Precautions
● Not recommended for patients with severe organic heart disease, acute renal disease, urinary retention, pheochromocytoma, or thyrotoxicosis due to potential adverse effects.
● Patients should avoid lying down during the daytime doses unless necessary to mitigate the risk of supine hypertension.
Drug Interactions
● Alpha-adrenergic blockers or other antihypertensive drugs could counteract Midodrine's therapeutic effects.
● Careful consideration should be given when combined with cardiac glycosides or beta-blockers due to possible additive or opposing effects.
● Drug interactions may lead to bradycardia or heart rhythm disturbances; therefore, monitoring is necessary.
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