Onglyza contains the active ingredient saxagliptin, which belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Saxagliptin works by increasing the release of insulin from the pancreas and decreasing the amount of sugar made by the liver. It helps to manage blood sugar levels without causing substantial weight gain, a common side effect of many other diabetes medications.

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Onglyza is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. It is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Onglyza is not for treating type 1 diabetes.

Additional information



● Type 2 Diabetes Mellitus (as part of a comprehensive treatment plan including diet, exercise, and possibly other medications)

Administration Guidelines

● Follow the healthcare provider's instructions regarding dosage and timing, typically once daily.

● Onglyza can be taken with or without food.

● Swallow the tablet whole and do not crush, chew, or break it.

● Consistency in the timing of the medication each day is recommended for optimal effect.

Administration Details

Dosage Forms:

● Oral tablet


● Typically prescribed as either 2.5 mg or 5 mg once daily, depending on individual needs, kidney function, and other factors.

● The healthcare provider may adjust the dosage based on the patient’s response and blood sugar levels.

Safety Precautions

● Pregnancy and Lactation: Speak to a healthcare provider to understand the risks and benefits of Onglyza during pregnancy and while breastfeeding.

● Pancreatitis Risk: If you experience severe abdominal pain, which may radiate to the back, with or without vomiting, contact your healthcare provider immediately.

● Heart Failure Risk: Monitor for signs and symptoms of heart failure; Onglyza has been associated with heart failure in some patients.

Drug Interactions

● Onglyza can interact with certain medications, including ketoconazole and other strong CYP3A4/5 inhibitors, which can increase saxagliptin levels in the blood. Always inform your healthcare provider about all the medications and supplements you're taking.

Side Effects

● Upper respiratory tract infections
● Urinary tract infections
● Headache
● Sinus infections
● Abdominal pain

Serious Side Effects

● Pancreatitis
● Heart failure
● Severe joint pain (arthralgia)
● Hypoglycemia, especially when used with other antidiabetic drugs
● Allergic reactions including anaphylaxis, angioedema, or skin reactions


● Store Onglyza at room temperature, away from moisture and heat.

● Keep the bottle tightly closed when not in use, and keep the medication out of the reach of children and pets.

Special Precautions

● Renal Impairment: Onglyza is not recommended for patients with severe renal impairment. For patients with moderate renal impairment, a lower dosage is advised.

● Hypoglycemia Risk: Combining Onglyza with other antidiabetic medications, such as sulfonylureas or insulin, increases the risk of hypoglycemia; monitor blood sugar levels closely.


● An overdose can potentially result in severe hypoglycemia. Immediate medical attention is necessary if an overdose is suspected, and treatment for hypoglycemia, such as taking glucose tablets or gel, should be initiated.


2.5MG, 5 MG


30 Tablets


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