The primary mechanism of pantoprazole lies in its ability to prevent the final step in gastric acid production. Pantoprazole suppresses acid secretion into the gastric lumen by binding to the gastric proton pump. This action relieves acid-related symptoms and allows the healing of ulcers and inflammation within the gastrointestinal tract. It has a longer duration of action compared to other antacids, making it suitable for once-daily dosing in many cases.

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Pantoprazole is a proton pump inhibitor (PPI) commonly prescribed to treat gastroesophageal reflux disease (GERD), stomach and duodenal ulcers, and other conditions associated with excessive stomach acid production. It works by irreversibly blocking the hydrogen-potassium ATPase enzyme system of the stomach’s parietal cells, effectively reducing gastric acid secretion. Pantoprazole is available as both an oral tablet and an intravenous (IV) medication.

Additional information



●Treatment of erosive esophagitis associated with GERD
●Long-term treatment and maintenance of healing of erosive esophagitis
●Treatment of Zollinger-Ellison Syndrome and other hypersecretory conditions
●Adjunctive treatment of duodenal and gastric ulcers

Administration Guidelines

●Oral Tablets: Pantoprazole oral tablets are usually taken once daily, 30 minutes before a meal, preferably in the morning. The delayed-release tablets should be swallowed whole without crushing, chewing, or splitting them to protect the medication's integrity until it is absorbed into the intestine.

●Intravenous Administration: Pantoprazole IV is for patients unable to take oral medication or when immediate acid suppression is needed. A healthcare professional should administer it.

Administration Details

Dosage Forms:

●Oral delayed-release tablets
●Intravenous (IV) powder for reconstitution


●The dosage of pantoprazole is individualized based on the condition being treated, the patient's age, liver function, and the overall treatment plan. It is imperative to adhere to the prescribing doctor’s recommended dosage.

Safety Precautions

●Pregnancy and Breastfeeding: Pantoprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to nursing mothers.

●Osteoporosis: Long-term usage and high doses of PPIs like pantoprazole may be associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine.

Drug Interactions

●Pantoprazole may reduce the absorption of drugs that require an acidic stomach environment, including ketoconazole, ampicillin esters, and iron salts. Additionally, because it can increase blood levels of methotrexate, caution is advised when used concomitantly.

Side Effects:

●Nausea or vomiting
●Abdominal pain

Serious Side Effects

●Severe allergic reactions including anaphylaxis
●Stevens-Johnson syndrome/toxic epidermal necrolysis
●Hypomagnesemia, especially with prolonged use
●Clostridium difficile-associated diarrhea
●Vitamin B12 deficiency, with long-term use


●Oral tablets should be stored at room temperature, away from excess heat and moisture. Do not store it in the bathroom.

●The IV form should be stored according to the manufacturer's instructions, usually at room temperature, and used within 12 hours of reconstitution.

Special Precaution

●Proper Administration Techniques: Ensure that extended-release tablets are taken intact to avoid premature release of medication.

●Monitoring: With long-term use, regular monitoring of magnesium levels, liver enzymes, and bone health may be necessary.


An overdose of pantoprazole does not typically result in life-threatening symptoms. However, large doses may cause confusion, drowsiness, blurred vision, tachycardia, nausea, and sweating. Treatment is supportive and symptomatic


20 MG, 40 MG


100 Tablets


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