Sporanox Solution


Sporanox Solution is an oral liquid medication intended for consumption. The solution provides an alternative for patients who may have difficulty swallowing pills or require a dosage adjustment that is easier to achieve with a liquid form. It’s particularly noted for its absorption qualities; food can significantly improve bioavailability.



Sporanox Solution contains the active ingredient itraconazole, a triazole antifungal agent. It is designed to treat fungal infections, such as oral and esophageal candidiasis, systemic infections like aspergillosis or blastomycosis, and other fungal conditions that do not respond to other treatments. It works by inhibiting the fungal enzyme synthesizing ergosterol, an essential component of the fungal cell membrane, thus disrupting cell membrane formation and leading to the fungus’s death.

Additional information



● Treatment of oropharyngeal and esophageal candidiasis.

● Used in systemic infections such as blastomycosis, histoplasmosis, and aspergillosis where initial therapy is appropriate.

● Onychomycosis in non-immunocompromised patients for whom a systemic treatment is necessary.

Administration Guidelines:


● Dosage varies based on the infection treated but generally involves taking the solution once or twice daily. It's crucial to follow the prescribing doctor's directions precisely.

Method of Administration:

● Oral route, ideally with food to enhance absorption. Shake the bottle well before each use.

Dosage Form:

● Sporanox Solution is available as a liquid for oral administration.

Safety Preclusions

Pregnancy and Breastfeeding:

● Sporanox is classified under FDA pregnancy category C. It should not be used during pregnancy unless the potential benefits justify the potential risk to the fetus. Caution is advised when Sporanox is administered to nursing mothers due to its potential excretion in human milk.

Long-term Use:

● Monitoring liver function is recommended for patients on long-term Sporanox therapy due to potential hepatotoxicity.

Drug Interactions:

● Sporanox has potential interactions with many drugs, notably those metabolized by P450 3A4. This includes statins, certain antihypertensives, and other antifungal medications, which could increase serum levels and potential toxicity.

Side Effects

● Nausea and vomiting
● Abdominal pain
● Diarrhea
● Headache

Serious Side Effects:

● Hepatic dysfunction
● Congestive heart failure
● Severe skin reactions, including Stevens-Johnson syndrome
● Neuropathy


● The solution should be stored at room temperature, away from light and moisture, and not in the bathroom. Keep the bottle tightly closed and out of reach of children.

Special Precautions

● Patients with existing liver dysfunction or a history of heart failure need careful assessment due to the risk of hepatic injury and the potential for exacerbating heart failure. All patients should regularly monitor liver function and signs of heart failure.


● Overdose symptoms may include headache, nausea, dizziness, and abdominal pain. There is no specific antidote for Sporanox overdose; treatment is supportive and symptomatic. In cases of significant overdose, gastric lavage may be considered. Patients should seek immediate medical attention if an overdose is suspected.


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