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Rufinamide’s precise mechanism of action is not fully understood, but it is believed to stabilize the nerve cell membrane by targeting sodium channels and limiting their activity during a neuron’s repetitive firing. By doing so, Banzel reduces the spread of electrical activity in the brain, which can lead to seizures.
Banzel, known by its generic name rufinamide, is an anticonvulsant medication approved specifically for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in children 4 years and older and adults. It is not typically used as a first-line treatment but is added to a patient’s current seizure medication regimen to help control seizures.
| Usage | Banzel is usually taken orally twice a day, with or without food. The dosage of rufinamide is based on the patient’s body weight and should be titrated according to the healthcare provider's instructions. The medication comes in tablets and a suspension for those who have difficulty swallowing pills. It is crucial to take Banzel consistently at the same times each day to maintain even levels of medication in the blood. Patients should not stop taking this medication without the guidance of a healthcare professional, as sudden discontinuation can lead to an increase in seizures. |
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| Side Effects | ● Headache ● Dizziness ● Fatigue ● Nausea ● Somnolence (drowsiness or sleepiness) Less common but more serious side effects include: ● Shortened QT interval, which can affect heart rhythm ● Severe allergic reactions such as rash, facial swelling, or difficulty breathing ● Multi-organ hypersensitivity reactions which could affect the liver or kidney function ● A significant increase in seizures when discontinuing the medication abruptly |
| Storage | Banzel should be stored at room temperature, away from light and moisture. Tablets should be kept in their original container, along with the packet or canister of moisture-absorbing preservatives. Liquid formulations should be used within 90 days of opening and do not require refrigeration. Keep the medication out of reach and sight of children and pets. |
| Special Precautions | Before starting Banzel, a detailed medical history should be shared with the healthcare provider, including any history of allergies, liver or kidney disease, or heart rhythm problems. Since Banzel can interact with other medications, it is important to list all current prescriptions, over-the-counter drugs, and supplements being taken. Banzel can reduce the effectiveness of hormonal contraceptives; alternative birth control methods should be discussed with a healthcare provider. Caution is advised when operating machinery or engaging in activities requiring mental alertness, as Banzel can cause dizziness and somnolence. Pregnant or breastfeeding women should discuss the potential risks and benefits of using Banzel with their healthcare provider. |
| Overdose | Signs of a Banzel overdose may include but are not limited to confusion, coordination problems, and being unusually sleepy or tired. In the event of an overdose, immediate medical attention is required. Treatment will typically be supportive and symptomatic, focusing on maintaining vital functions and managing any clinical signs or symptoms that may occur. |
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