Esomeprazole is the S-isomer of omeprazole, offering improved pharmacokinetic properties and efficacy compared to its racemic predecessor. Directly inhibiting the H+/K+ ATPase enzyme system (the “proton pump”) in the stomach’s acid-secreting parietal cells significantly diminishes basal and stimulates gastric acid production. This makes it effective for treating acid-related disorders and preventing potential complications associated with excessive stomach acid.

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Esomeprazole, marketed under the brand Nexium, among others, is a proton pump inhibitor (PPI) used to reduce stomach acid. It is highly effective in treating conditions like gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. Esomeprazole blocks the stomach wall’s proton pump, which is responsible for acid production. This action relieves symptoms and allows the digestive system’s lining to heal. It comes in various forms, including capsules, tablets, and injectable solutions.

Additional information



● Gastroesophageal Reflux Disease (GERD): For treating erosive esophagitis and symptom relief.
● Peptic Ulcer Disease: Prevention of relapse in patients with healed ulcers.
● Zollinger-Ellison Syndrome: Management of pathologically hypersecretory conditions, including this rare condition that causes the stomach to produce too much acid.
● Prevention of NSAID-Induced Ulcers: Protects against ulcers caused by long-term NSAID use.

Side Effects

● Headache
● Diarrhea
● Nausea
● Stomach pain
● Gas
● Constipation
● Dry mouth

Serious side effects requiring medical attention include:

● Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
● Kidney issues (urinary changes, swelling, rapid weight gain)
● Magnesium imbalances (irregular heartbeat, persistent muscle spasms, seizures)


Store Esomeprazole at room temperature, between 20°C to 25°C (68°F to 77°F), in a tightly closed container to protect from moisture. Keep it out of reach of children and pets, and do not store it in areas exposed to excessive heat or moisture.

Special Precautions

Before starting Esomeprazole, disclose your complete medical history, especially:

● Liver disease
● Lupus
● Osteoporosis or low bone mineral density
● Magnesium or vitamin B12 deficiency


Symptoms of an overdose may include confusion, blurred vision, drowsiness, dry mouth, flushing, and headache. If an overdose is suspected, seek immediate medical attention or contact a poison control center right away.


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