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Mekinist (Trametinib dimethyl sulfoxide)

$4,205.00

Trametinib, either alone or in conjunction with another medication called dabrafenib (Tafinlar), is prescribed to treat specific forms of melanoma (a type of skin cancer) that cannot be surgically treated or have metastasized.

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Description

Trametinib, either alone or in conjunction with another medication called dabrafenib (Tafinlar), is prescribed to treat specific forms of melanoma (a type of skin cancer) that cannot be surgically treated or have metastasized. Trametinib is also used alongside dabrafenib to manage a certain type of non-small-cell lung cancer (NSCLC) that has spread. It belongs to a class of drugs known as kinase inhibitors, which function by inhibiting the activity of abnormal proteins that drive the multiplication of cancer cells, thereby halting their spread.

Additional information

Usage

Usage
Trametinib is available in tablet form for oral administration. Typically, it is taken once daily on an empty stomach, at least 1 hour before or 2 hours after a meal. It's essential to maintain a consistent schedule, taking trametinib at the same time each day. Follow the instructions provided on your prescription label meticulously, and if you have any questions, consult your doctor or pharmacist for clarification. Adhere to your doctor's prescribed dosage, and do not alter it without their guidance. Avoid discontinuing trametinib treatment without consulting your doctor. They may adjust your trametinib dosage based on your treatment response and any potential side effects. Throughout your treatment, maintain open communication with your doctor regarding your well-being. You can also request a copy of the manufacturer's patient information from your pharmacist or doctor.

Side Effects

Side Effects
Trametinib may lead to side effects. If any of the following symptoms become severe or persistent, inform your doctor:
• Dry skin
• Mouth and tongue sores
• Dry mouth
• Vomiting
• Loss of appetite
• Changes in taste perception
• Fatigue
Some side effects can be serious. Cease trametinib use and contact your doctor immediately if you experience any of these symptoms:
• Unusual bleeding or bruising
• Bloody or black, tarry stools
• Coughing up blood or expelling vomit resembling coffee grounds
• Nosebleeds
• Diarrhea
• Stomach pain
• Nausea
• Fever
• Chills
• Rapid, irregular, or pounding heartbeat
• Breathing difficulties
• Chest pain
• Edema or swelling in the facial, arm, leg, ankle, or foot regions
• Dizziness, lightheadedness, or weakness
• Severe headaches
• Shortness of breath
• Cough
• Blurred vision
• Changes in vision, such as seeing halos or colored dots
• Loss of vision
• Eye pain
• Dry, red, or swollen eyes
• Rash, red skin, or pimples
• Itching
• Skin or nail blisters, ulcers, or sores
• Tingling, burning, redness, swelling, peeling, flaking, blisters, or sores on palms or soles
• Increased urination
• Excessive thirst
Trametinib may elevate the risk of developing other cancers, including new skin cancers. Discuss these potential risks with your doctor. Additionally, trametinib may cause other side effects. Contact your doctor if you encounter any unusual issues while using this medication.

Storage

Storage
-Store this medication in its original container, securely closed, and out of children's reach. Do not transfer the tablets to other containers, such as daily or weekly pill organizers. Keep it in the refrigerator, but do not freeze it, and leave the desiccant (a moisture-absorbing packet included with the medication) in the bottle. Safeguard all medications from children; many containers, including weekly pill organizers and those for eye drops, creams, patches, and inhalers, are not child-resistant and can be easily opened by young children. To prevent accidental ingestion by children, always use safety caps and store the medication in a safe, out-of-sight location.

Special Precautions

Special Precautions
Before starting trametinib treatment, inform your doctor and pharmacist of any known allergies to trametinib, other medications, or any components in trametinib tablets. Inquire with your pharmacist for a list of the ingredients.
Share with your healthcare providers the details of all prescription and over-the-counter medications, vitamins, supplements, and herbal products you currently use or intend to take.
Discuss any medical conditions you have or had, including lung disease, diabetes, bleeding disorders, colitis, gastrointestinal issues, high blood pressure, heart, eye, liver, kidney problems, or other health conditions.
If you are pregnant or planning pregnancy, avoid trametinib as it may harm the fetus. Use effective birth control during trametinib treatment and for four months after your last dose. Consult your doctor about suitable contraception methods.
For nursing mothers or those planning to breastfeed, trametinib is not recommended. Avoid breastfeeding during trametinib treatment and for four months after the final dose.

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