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Methazolamide works by inhibiting the enzyme carbonic anhydrase, which plays a significant role in producing aqueous humor – the fluid in the eye. By decreasing fluid production, methazolamide effectively reduces pressure within the eye, offering relief and preventing further eye damage in patients with glaucoma. Its systemic mechanism allows for the treatment of both eyes simultaneously, making it a valuable option for patients with bilateral conditions.



Methazolamide, a carbonic anhydrase inhibitor, is critical in the medical field for managing conditions like glaucoma. Reducing the production of aqueous humor in the eyes, it helps lower intraocular pressure, which is crucial for patients with glaucoma or other ocular hypertension conditions. It’s known for its ease of oral administration, distinguishing it from many treatments requiring topical application or more invasive procedures.

Additional information



● Reduction of intraocular pressure in the treatment of glaucoma.
● Management of ocular hypertension.

Patients Should:

● Adhere strictly to the prescribed dosage to avoid potential side effects.
● Inform their healthcare provider about any pre-existing conditions, such as kidney or liver diseases, adrenal gland disorders, or electrolyte imbalances.
● Consult their healthcare provider if they are pregnant, planning a pregnancy, or breastfeeding.
● Be aware of potential side effects and contact their healthcare provider if they experience severe reactions.



● Oral tablets which should be taken with a glass of water, with or without food, as directed by the healthcare provider.


● Not recommended for patients with severe kidney or liver problems, adrenal gland issues, or who are sensitive to sulfonamides.
● Patients with electrolyte imbalances (e.g., hypokalemia or hyponatremia) need careful monitoring due to the drug's diuretic effect.
● Regularly monitoring intraocular pressure, electrolyte levels, and blood counts is advised during therapy.

Drug Interactions

● Methazolamide may interact with aspirin, other carbonic anhydrase inhibitors, and drugs that cause electrolyte imbalances. Patients must inform their healthcare provider of all current medications and supplements.

Side Effects

● Fatigue
● Dizziness
● Nausea
● Increased urination

Severe side effects requiring immediate attention:

● Signs of allergic reaction (hives, difficulty breathing, swelling of face or throat)
● Blood cell disorders (easy bruising or bleeding, unusual weakness)
● Electrolyte imbalances (confusion, irregular heartbeat, increased thirst)
● Severe skin reactions


● Tablets should be stored at room temperature, in a dry place away from direct light.

Special Precautions

● Before starting treatment, a comprehensive medical history, including allergies, current medications, and pre-existing conditions, should be discussed with the healthcare provider.
● Patients should understand the potential impact on activities requiring alertness, as methazolamide can cause dizziness or fatigue.


● Overdose symptoms may include drowsiness, confusion, or a decrease in the amount of urine. Immediate medical attention should be sought if an overdose is suspected.


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