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The active substance in nadolol, also known by the brand name Corgard, is a non-selective beta-adrenergic receptor blocker that does not have intrinsic sympathomimetic activity or membrane-stabilizing activity. It reduces the heart’s oxygen demand and cardiac output, which results in decreased blood pressure and heart rate. Nadolol is often used when other interventions have not been sufficient in managing hypertension or angina.
Nadolol is a medication belonging to a class of drugs known as beta-blockers. It is used primarily to treat high blood pressure (hypertension) and to prevent chest pain (angina). By reducing the workload on the heart and opening up the blood vessels, nadolol helps the heart to beat more regularly and with less force.
| Usage | Indications: ● Hypertension: Nadolol is effective in lowering high blood pressure, thereby reducing the risk of stroke, heart attack, and kidney problems. ● Angina Pectoris: The drug is used for the long-term management of angina to reduce the frequency and severity of angina attacks. ● Cardiac Arrhythmias: Although less common, it may be used for treating certain types of arrhythmias. ● Migraine Prevention: Nadolol may sometimes be prescribed for the prevention of migraine headaches. Patient Guidelines Patients prescribed nadolol should: ● Adhere strictly to the prescribed dosage and schedule. ● Avoid sudden discontinuation of the drug, as this can lead to a rapid increase in blood pressure or angina symptoms. ● Monitor their blood pressure regularly. ● Inform their healthcare provider about their complete medical history, specifically if they have asthma, bronchitis, diabetes, or issues with circulation. ● Be aware that certain physical symptoms of low blood sugar (hypoglycemia) may be masked by nadolol. Administration Details How to Use Nadolol: ● Oral Administration: Nadolol is administered orally, usually once a day, with or without food. Dosage: ● The dosage of nadolol is individualized based on the medical condition, response to treatment, and other medications a patient may be taking. It is critical to follow the dosing instructions provided by a healthcare provider. Safety Precautions ● Pregnancy and Lactation: Nadolol should be used during pregnancy only if clearly needed and after a thorough assessment of the risks and benefits. Caution should also be exercised when nadolol is administered to a nursing mother. ● Allergic Reactions: Patients should be advised to immediately report signs of an allergic reaction or difficulty breathing. Drug Interactions Potential drug interactions with nadolol include: ● Antidiabetic Drugs: Nadolol may mask the symptoms of hypoglycemia in diabetic patients. ● Respiratory Medications: There can be a negative interaction with asthma medications due to nadolol's effects on the respiratory system. ● Calcium Channel Blockers and Other Antihypertensives: Concomitant use may increase the risk of a significant drop in blood pressure. ● NSAIDs: May reduce nadolol’s antihypertensive effects. |
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| Side Effects | ● Fatigue Serious Side Effects Immediate medical attention should be sought for: ● Breathing problems or wheezing |
| Storage | ● Nadolol should be stored at room temperature, away from light and moisture, and out of reach of children and pets. |
| Special Precautions | ● Monitoring: Blood pressure and heart rate should be regularly monitored while on nadolol therapy. ● Abrupt Discontinuation: To avoid acute tachycardia, hypertension, and/or ischemia, nadolol should not be abruptly discontinued, especially in patients with ischemic heart disease. ● Heart Failure: Caution should be taken when using nadolol in patients with heart failure controlled by digitalis and diuretics. |
| Overdose | ● Symptoms of a nadolol overdose may include severe dizziness, fainting, or slow/irregular heartbeat. Treatment of overdose is aimed at supporting vital functions, closely monitoring and possibly adjusting doses of concomitant medications, and treating symptomatically. Activated charcoal and/or medications to improve heart rate or contractility may be used under medical supervision. |
| MG | 40 MG, 80 MG, 160 MG |
| Tablets | 100 Tablets |
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