Pioglitazone functions by binding to peroxisome proliferator-activated receptors (PPARs) found in the body’s tissue, specifically the PPAR-gamma receptors in fat cells, liver cells, and skeletal muscle cells. Activation of PPAR-gamma receptors modulates the transcription of insulin-responsive genes involved in the control of glucose and lipid metabolism. By improving the efficiency of insulin, pioglitazone reduces blood glucose levels and lowers the need for exogenous insulin administration in patients. Its precise action helps alleviate the insulin resistance characteristic of type 2 diabetes, offering a strategic approach to managing this chronic condition.

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Pioglitazone is a medication used primarily to treat type 2 diabetes mellitus, a condition characterized by high blood sugar levels and insulin resistance. It belongs to the class of drugs known as thiazolidinediones. It works by increasing the body’s sensitivity to insulin, thereby enhancing glucose utilization and improving glycemic control. Pioglitazone is available in tablet form and is often used in conjunction with diet and exercise to achieve optimal blood sugar management in patients with type 2 diabetes.

Additional information


●Management of type 2 diabetes mellitus

●As monotherapy or in combination with other antidiabetic agents such as metformin, a sulfonylurea, or insulin when additional blood sugar control is needed

Administration Guidelines

●Oral Tablets: Pioglitazone is typically administered once daily, with or without food. Consistent daily dosing is recommended to maximize therapeutic outcomes. It's crucial to swallow the tablets whole without crushing or breaking them to ensure proper drug release and absorption.

Administration Details

Dosage Forms:

●Oral tablets


●The initial and maintenance dosages of pioglitazone are individualized based on the patient's current treatment regimen, effectiveness, and tolerability. Dosage adjustments are often made based on periodic assessments of the patient's blood sugar levels to ensure optimal diabetes control.

Safety Precautions

●Pregnancy and Breastfeeding: The safety of pioglitazone in pregnant women or nursing mothers is not well-established. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, and caution is advised if administered to nursing mothers.

●Heart Failure: Pioglitazone may cause or worsen heart failure. It should be used with caution in patients with a history of heart failure, and monitoring for signs and symptoms of heart failure is recommended during treatment.

Drug Interactions

●Pioglitazone may interact with other medications, including insulin and other antidiabetic drugs, leading to an increased risk of hypoglycemia. Additionally, it may affect the metabolism of drugs metabolized by cytochrome P450 enzymes, necessitating dosage adjustments or close monitoring.

Side Effects:

●Weight gain
●Edema (swelling)
●Upper respiratory tract infections

Serious Side Effects

●New or worsening heart failure
●Bladder cancer risk (especially with long-term use)
●Fractures in women


●Pioglitazone tablets should be stored at room temperature, away from moisture and direct sunlight. To protect them from exposure to the environment, keep the medication in its original packaging until use.

Special Precaution

●Proper Administration Techniques: Ensure patients are educated on the importance of adhering to their prescribed dosing schedule and the proper storage of the medication to maintain its efficacy.

●Monitoring: Regular monitoring of liver function tests, glycemic control, and signs of heart failure is essential throughout treatment with pioglitazone. Periodic assessment of the risk versus benefit is recommended in patients with a significant risk of developing bladder cancer.


An overdose of pioglitazone can potentially lead to excessive lactic acid in the blood (lactic acidosis), a severe and sometimes fatal condition. Symptoms of overdose may include hypoglycemia, nausea, vomiting, and diarrhea. Immediate medical intervention is necessary in the event of an overdose


15 MG, 30 MG, 45 MG


100 Tablets


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