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Tacrolimus functions primarily by inhibiting calcineurin, a critical enzyme in the immune system’s T cells. This inhibition prevents the transcription of interleukin-2 and other cytokines, which are vital for the activation of T lymphocytes. By suppressing this cellular immune response, Prograf effectively prevents the acute rejection of transplanted organs by the body’s immune system, thereby aiding in the prolonged survival of organ implants.
Prograf, known generically as tacrolimus, is a potent immunosuppressive medication used extensively in transplant medicine to prevent organ rejection. It is classified as a calcineurin inhibitor and is essential in maintaining the longevity of transplanted organs by suppressing the immune response that could potentially attack the transplanted tissue. Prograf is available in various forms, including capsules, an oral suspension, and an intravenous infusion solution.
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