Sertraline is available in tablet and oral concentrate form and is intended for oral administration. The goal of sertraline treatment is to correct the chemical imbalances of neurotransmitters in the brain that are believed to be responsible for changes in mood and behavior. SSRIs like sertraline limit the reabsorption of serotonin into neurons, making more serotonin available to improve the transmission of messages between neurons.

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Sertraline, commonly known under the brand name Zoloft, is an oral antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class of medications. It is prescribed for the treatment of a variety of mental health conditions, including major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Sertraline functions by increasing serotonin levels in the brain, which can improve mood and reduce symptoms of anxiety and depression.

Additional information



● Treatment of major depressive disorder (MDD) in adults and pediatric patients aged 6-17 years.

● Management and reduction of symptoms in obsessive-compulsive disorder (OCD) in both adults and pediatric patients (6-17 years).

● Treatment of panic disorder, including prevention of panic attacks.

● Alleviation of symptoms related to social anxiety disorder.

● Management of post-traumatic stress disorder (PTSD).

● Mitigation of symptoms associated with premenstrual dysphoric disorder (PMDD).

Administration Guidelines:

● Sertraline can be taken with or without food. The tablets should be taken with water, and the oral concentrate must be diluted before use.

● Dosages vary depending on the condition being treated and individual patient factors. Compliance with healthcare provider instructions is imperative.

● To minimize side effects, sertraline is often started at a low dose and gradually increased.

● For consistent blood levels, sertraline should be taken at the same time each day.

Dosage Forms:

● Tablets: 25 mg, 50 mg, 100 mg.
● Oral Concentrate: 20 mg/mL, typically accompanied by a dropper for precise dosing.

Safety Preclusions

Pregnancy and Breastfeeding:

● The potential risks and benefits of using sertraline during pregnancy or breastfeeding should be carefully weighed. There's evidence suggesting a risk of fetal harm when used during the third trimester.

● Sertraline is excreted in breast milk so caution should be exercised when administered to nursing women.

Long-term Use:

● Long-term use may be warranted for individuals with chronic conditions, but regular monitoring for efficacy and side effects should be maintained.

Drug Interactions:

● Sertraline should not be administered in conjunction with MAO inhibitors or within 14 days of stopping them.

● Care should be taken when used concurrently with other medications that increase serotonin levels to avoid serotonin syndrome.

Side Effects

● Nausea, diarrhea, or loose stools.
● Dry mouth.
● Changes in appetite or weight.
● Sleepiness or insomnia.
● Increased sweating.

Serious Side Effects:

● Increased risk of suicidal thoughts and actions in children, adolescents, and young adults.

● Serotonin syndrome, especially when combined with other serotonergic drugs.

● Severe allergic reactions.


● Tablets should be stored at controlled room temperature, away from moisture and heat.

● If using the oral concentrate, store the bottle tightly closed and dispose of any unused portion after 60 days.

Special Precautions

● Sertraline should be tapered gradually when discontinuing treatment to avoid withdrawal symptoms.

● Monitoring of suicidal ideation and behavior is recommended, specifically during the initial treatment phase and during dose adjustments.


● An overdose of sertraline can result in symptoms such as dizziness, tremor, agitation, seizure, or coma, and should be treated as a medical emergency with immediate care from healthcare professionals.

● Management of overdose should include symptomatic and supportive measures.


25 MG, 50 MG, 100 MG


100 Capsules


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