Indications:
● Treatment of oropharyngeal and esophageal candidiasis.
● Used in systemic infections such as blastomycosis, histoplasmosis, and aspergillosis where initial therapy is appropriate.
● Onychomycosis in non-immunocompromised patients for whom a systemic treatment is necessary.
Administration Guidelines:
Dosage:
● Dosage varies based on the infection treated but generally involves taking the solution once or twice daily. It's crucial to follow the prescribing doctor's directions precisely.
Method of Administration:
● Oral route, ideally with food to enhance absorption. Shake the bottle well before each use.
Dosage Form:
● Sporanox Solution is available as a liquid for oral administration.
Safety Preclusions
Pregnancy and Breastfeeding:
● Sporanox is classified under FDA pregnancy category C. It should not be used during pregnancy unless the potential benefits justify the potential risk to the fetus. Caution is advised when Sporanox is administered to nursing mothers due to its potential excretion in human milk.
Long-term Use:
● Monitoring liver function is recommended for patients on long-term Sporanox therapy due to potential hepatotoxicity.
Drug Interactions:
● Sporanox has potential interactions with many drugs, notably those metabolized by P450 3A4. This includes statins, certain antihypertensives, and other antifungal medications, which could increase serum levels and potential toxicity.
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