Indications:
● Synvisc is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond to conservative non-pharmacologic therapy and simple analgesics.
Administration Guidelines
Dosage
● Synvisc-One: A single injection of 6mL directly into the knee joint.
● Traditional Synvisc: Three injections, each of 2mL, administered one week apart.
Method of Administration
● The injection should be administered by a healthcare professional trained in the technique, directly into the knee joint through sterile technique.
Dosage Form
● Synvisc is available as a viscoelastic, sterile, non-pyrogenic, elastoviscous fluid in pre-filled syringes for intra-articular injection.
Safety Preclusions
Pregnancy and Breastfeeding
● The safety of Synvisc in pregnant or breastfeeding women has not been established. It should be used only if needed and after a thorough risk/benefit analysis.
Long-term Use
● Long-term effects beyond six months are not well established. Treatment effectiveness and the need for repeat injections should be evaluated case-by-case.
Drug Interactions
● There are no known significant drug interactions with Synvisc. However, it is recommended to avoid using disinfectants containing quaternary ammonium salts for skin preparation as they may precipitate with hyaluronic acid.
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