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Methimazole is available in tablet form for oral administration. It is typically prescribed to be taken multiple times a day according to the severity of the thyroid hormone excess. The therapeutic effects on hyperthyroid symptoms are generally observed within one to two weeks of starting treatment, with optimal improvement seen over several weeks or months.
Tapazole, which is the brand name for methimazole, is a medication most commonly used to manage hyperthyroidism, a condition characterized by an overactive thyroid gland. It is part of a class of medications known as thioamides and works by inhibiting the production of thyroid hormones. By reducing the levels of thyroid hormones, Tapazole helps to alleviate symptoms associated with hyperthyroidism, including rapid heart rate, excessive sweating, weight loss, and nervousness.
| Usage | Indications: ● Tapazole is indicated for the treatment of hyperthyroidism and its symptoms. It is also used as preparation for thyroidectomy or radioactive iodine therapy in the management of thyroid disorders. Administration Guidelines Dosage Adults: ● The initial dosage can vary widely based on the severity of the condition, typically ranging from 5 mg to 60 mg daily, split into 2 or 3 doses. Maintenance dosages are generally lower, adjusted according to patient response and thyroid hormone levels. Method of Administration ● Tablets: Should be taken orally, with or without food based on individual tolerance. It's important not to crush or chew the tablets unless a healthcare provider advises. Dosage Form Tapazole is available as: ● Tablets in various strengths, commonly 5 mg and 10 mg. Safety Preclusions Pregnancy and Breastfeeding ● Tapazole is associated with risk to the fetus and is generally not recommended during pregnancy, particularly in the first trimester, unless necessary. Alternative treatments may be preferred. Methimazole can pass into breast milk, so caution is advised when used during breastfeeding. Drug Interactions ● Tapazole can interact with blood thinners, beta-blockers, and other medications, potentially altering their effects. Patients must inform their healthcare provider about all their medications and supplements. |
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| Side Effects | ● Patients may experience gastrointestinal discomfort, headache, mild rash, itching, or muscle pain. Most of these effects are mild and temporary. Serious Side Effects ● Although rare, methimazole can cause severe liver problems, agranulocytosis (a severe drop in white blood cells), and other blood disorders. Symptoms such as unexplained fever, sore throat, bruising, or jaundice require immediate medical attention. |
| Storage | ● Tapazole tablets should be stored at room temperature, away from light and moisture, ideally between 15°C and 30°C (59°F and 86°F). |
| Special Precautions | ● Patients with liver disease, blood disorders, or those undergoing treatment for other conditions require careful monitoring and dose adjustments. Regular thyroid function tests and blood counts are recommended to monitor the treatment's effectiveness and detect potential side effects early. |
| Overdose | ● Symptoms of overdose may include rapid heart rate, nausea, vomiting, restlessness, and even confusion. In cases of suspected overdose, immediate medical attention is necessary to provide supportive care and treatment. |
| MG | 5 MG, 10 MG |
| Tablets | 100 Tablets |
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