Sertraline functions by inhibiting the reuptake of serotonin in the central nervous system, which elevates the mood and decreases the symptoms of depression and anxiety. Its effect on serotonin levels makes it effective in treating a wide range of mental health conditions. It has a favorable pharmacokinetic profile with once-daily dosing due to its relatively long half-life.

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Zoloft, with the generic name sertraline, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is primarily indicated for the treatment of major depressive disorder (MDD), and anxiety disorders—including obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD)—and premenstrual dysphoric disorder (PMDD). SSRIs like Zoloft work by increasing serotonin levels, a neurotransmitter in the brain that helps maintain mental balance. This increase can help improve mood, sleep, and appetite and may decrease anxiety, fear, unwanted thoughts, and the number of panic attacks.

Additional information



● Major Depressive Disorder (MDD): For the treatment of depression and its related symptoms.

● Anxiety Disorders: Includes the treatment of OCD, panic disorder, social anxiety disorder, PTSD, and the prevention of relapse.

● Premenstrual Dysphoric Disorder (PMDD): Helps in managing premenstrual mood swings, irritability, and other symptoms.

Administration Guidelines


● Sertraline dosage varies depending on the treated condition, typically from 25 mg to 200 mg daily. It is crucial to follow a healthcare provider's prescription closely
● Initial dosages are often lower, gradually increasing based on patient response and tolerability.

Method of Administration:

● Oral: Zoloft is available in tablets and an oral liquid solution. Tablets should be swallowed whole with water or another liquid. The oral solution should be diluted before use as specified in the product's instructions.

Dosage Form:

● Tablets: Typically available in 25 mg, 50 mg, and 100 mg dosages.
● Oral Concentrate: A liquid form for dilution.

Safety Preclusions

Pregnancy and Breastfeeding:

● Zoloft should be used during pregnancy only when needed and after considering the potential risks and benefits. If used during the late stages of pregnancy, it could lead to complications for the newborn.

● It is known to pass into breast milk, so nursing mothers should consult their healthcare provider for advice.

Drug Interactions:

● Sertraline can interact with a wide range of medications, including but not limited to MAO inhibitors, other SSRIs, blood thinners, and certain migraine medications. It is crucial to disclose all medications, including over-the-counter drugs and supplements, to the prescribing healthcare provider.

Side Effects

● Nausea
● Diarrhea or loose stools
● Tremor
● Insomnia or drowsiness
● Sexual dysfunction

Serious Side Effects:

● Serotonin syndrome, a potentially life-threatening condition
● Suicidal thoughts or behaviors, especially in young adults and adolescents
● Severe allergic reactions, including rash, hives, swelling, and difficulty breathing
● Seizures


● Zoloft should be stored at room temperature, between 15°C to 30°C (59°F to 86°F).
● Keep it securely closed and out of the reach of children.

Special Precautions

● Starting an SSRI antidepressant, including Zoloft, may increase the risk of suicidal thoughts or attempts, especially in children, adolescents, and young adults within the first few months or when the dose is changed. Patients should be closely monitored for significant changes in behavior.

● Abrupt discontinuation should be avoided to prevent withdrawal symptoms; a gradual dose reduction under medical supervision is recommended.


● Overdose of Zoloft can lead to symptoms such as dizziness, tremors, agitation, seizures, or coma. Immediate medical attention is crucial in the event of an overdose.


25 MG, 50 MG, 100 MG


100 Capsules


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