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Allopurinol is a xanthine oxidase inhibitor that diminishes the body’s production of uric acid. By inhibiting the enzyme xanthine oxidase, allopurinol prevents the oxidation of purines to uric acid, thereby reducing the levels of uric acid in the blood and minimizing the risk of gouty arthritis and kidney stones.
Zyloprim, the brand name for allopurinol, is primarily used to treat gout, characterized by sudden and severe attacks of pain, redness, and tenderness in the joints. Allopurinol effectively reduces the production of uric acid in the body, thus preventing gout flares and ultimately reducing the occurrence of gouty arthritis, kidney stones, and elevated uric acid levels that may occur after cancer therapy.
| Usage | Indications: ● Gout: Used to manage gout, preventing gout attacks. Administration Guidelines Dosage and Application: ● Gout: Initial dosage for adults may start at 100 mg daily and gradually increase based on the patient's response and serum urate levels, not exceeding 800 mg per day. ● Kidney Stones and Hyperuricemia: Dosages may vary. Follow the healthcare provider's prescription. Method of Administration: ● Oral Tablet: Zyloprim is taken by mouth, usually once daily after a meal to reduce the risk of stomach upset. ● Hydration: Encourage patients to drink plenty of fluids while taking this medication to prevent kidney stones. Safety Preclusions Pregnancy and Breastfeeding: ● Consultation with a healthcare provider is essential as allopurinol crosses the placenta and is excreted in breast milk. Drug Interactions: ● Alert your healthcare provider to all medications you take, as allopurinol can interact with drugs like azathioprine, warfarin, and certain antibiotics. |
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| Side Effects | ● Upset stomach Serious Side Effects: ● Skin rash, which may be a sign of a severe reaction requiring immediate medical attention. ● Hepatic issues, like hepatitis. ● Renal impairment. |
| Storage | ● Store Zyloprim at room temperature, away from moisture and light. |
| Special Precautions | ● Allopurinol may cause drowsiness; caution should be exercised when driving or performing tasks requiring alertness. ● Address any signs of liver problems, such as yellowing of the skin/eyes or abdominal pain, to a physician. ● Zyloprim is not a pain reliever and won’t work during an acute gout attack. |
| Overdose | ● Seek emergency medical attention or contact a Poison Control Center right away if an overdose is suspected. |
| MG | 100 MG, 200 MG, 300 MG |
| Tablets | 100 Tablets |
