Anafranil, clinically known as clomipramine, is a prescription medication primarily used to treat obsessive-compulsive disorder (OCD). It belongs to a class of drugs known as tricyclic antidepressants (TCAs) and works by increasing the levels of serotonin, a natural substance in the brain that helps maintain mental balance.

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The active ingredient in Anafranil is clomipramine hydrochloride. It functions by inhibiting the reuptake of serotonin, leading to an increase in the synaptic concentration of serotonin in the central nervous system, which is believed to be beneficial in addressing the symptoms of OCD.

Additional information


Anafranil is taken orally, with or without food, usually 1 to 3 times daily or as directed by the healthcare provider. Starting doses are typically low and gradually increased to minimize possible side effects. It comes in capsule form and should be taken whole with a glass of water. The dose is based on the patient's medical condition and response to treatment. Anafranil should be taken regularly at the same time(s) each day to achieve the best effect.

Side Effects

● Dry mouth ● Dizziness ● Drowsiness ● Constipation ● Nausea ● Weight changes ● Difficulty urinating ● Increased sweating Less common but more serious side effects may include: ● Severe heartburn or stomach pain ● Easy bruising or bleeding ● Seizures ● Irregular heartbeat ● Mental/mood changes (e.g., confusion, agitation, hallucinations)


Store Anafranil at room temperature, away from light and moisture. Keep it out of the bathroom and beyond the reach of children and pets. Ensure the bottle is tightly closed when not in use. Properly dispose of any medication that is outdated or no longer needed in accordance with local waste disposal regulations.

Special Precautions

Before taking Anafranil, patients must discuss their medical history with their doctor, especially focusing on heart problems, liver disease, seizure disorders, thyroid problems, glaucoma, or urinary retention. The medication can interact with several drugs; thus, it's important to inform healthcare providers about all medications, including over-the-counter drugs and supplements being taken. Anafranil may cause drowsiness or dizziness, so patients should be cautious when driving or performing tasks requiring alertness. During pregnancy, Anafranil should be used only when clearly needed. Discuss the risks and benefits with your healthcare provider. The medication passes into breast milk and could have undesirable effects on a nursing infant, making it crucial to consult a healthcare provider before breastfeeding.


Symptoms of an overdose may include severe drowsiness, seizures, or irregular heartbeat. In the event of an overdose, immediate medical attention is required. Contact emergency services if someone has overdosed and presents serious symptoms such as passing out or trouble breathing. An overdose of Anafranil can be serious and requires urgent treatment in a hospital setting.


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