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Entresto (Sacubitril and Valsartan)

$222.79

Entresto combines the medications valsartan and sacubitril. It is typically prescribed for individuals with heart failure to reduce the risk of death and hospitalization due to cardiac events like heart attacks and strokes. It should be used in conjunction with other heart medications as directed by your healthcare provider.

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Description

Entresto combines the medications valsartan and sacubitril. It is typically prescribed for individuals with heart failure to reduce the risk of death and hospitalization due to cardiac events like heart attacks and strokes. It should be used in conjunction with other heart medications as directed by your healthcare provider.

Sacubitril, one of the active ingredients, acts as a neprilysin inhibitor. Neprilysin is responsible for breaking down specific protein molecules in the kidneys, which play a protective role for both the kidneys and the heart.

The second active ingredient, valsartan, belongs to the class of angiotensin II receptor blockers (ARBs) and is commonly used to manage high blood pressure when prescribed as a standalone medication. When combined with sacubitril, valsartan helps alleviate stress on the heart in cases of heart failure.

Additional information

Usage

Usage
Entresto is available in the following dosage forms:
• Sacubitril/Valsartan 24/26 mg
• Sacubitril/Valsartan 49/51 mg
• Sacubitril/Valsartan 93/103 mg
The usual starting dose is one tablet of Entresto 24/26 mg taken orally twice daily. Following a period of two to four weeks, the dosage may be escalated to Entresto 49/51 mg taken orally twice daily. Subsequently, after an additional two to four weeks, the dose may be increased to Entresto 97/103 mg taken twice daily.

Side Effects

Side Effects
The possible side effects of Entresto may include:
• Cough
• Reduced hematocrit
• Decreased hemoglobin
• Dizziness
• Dizziness
• Elevated blood potassium levels
• Increased blood creatinine
• Kidney failure
• Low blood pressure

Storage

Storage
Store Entresto at a controlled room temperature, ideally between 20°C to 25°C (77°F). Avoid storing Entresto in areas with high moisture, such as the bathroom or kitchen.

Precaution

Precaution
If you were previously using an ACE inhibitor, it's important to discontinue the ACE inhibitor and wait at least 36 hours before initiating Entresto. Some examples of ACE inhibitors include:
• Benazepril
• Captopril
• Enalapril
• Fosinopril
• Lisinopril
• Quinapril
• Ramipril
If you have diabetes, it is not advisable to take Tekturna (aliskiren) and Entresto simultaneously.
Additionally, if you have previously used an ACE inhibitor or ARB and encountered skin swelling, you should avoid taking Entresto.

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