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Isosorbide Dinitrate

Original price was: $45.00.Current price is: $35.95.

Isosorbide Dinitrate releases nitric oxide, which stimulates the relaxation of smooth muscle cells in the blood vessel walls, resulting in vasodilation. This process significantly increases blood flow to the myocardium (heart muscle) and simultaneously reduces the heart’s oxygen demand. The medication is beneficial in managing symptoms of angina pectoris and improving the quality of life in patients with certain types of heart disease.



Isosorbide Dinitrate is an oral medication primarily used to treat and prevent angina pectoris, a type of chest pain associated with coronary artery disease. It belongs to a class of drugs known as nitrates, which help to relax and widen blood vessels. This action allows blood to flow more easily to the heart, reducing the heart’s workload and the risk of an angina attack. Isosorbide Dinitrate is available in tablet form, including immediate-release and extended-release formulations, and is sometimes prescribed alongside other cardiovascular medications.

Additional information


Isosorbide Dinitrate is indicated for:

● The prevention and treatment of angina pectoris.
● As part of the treatment regimen for chronic heart failure, under specific conditions.

Patients are advised to:

● Follow the prescribed dosage regimen by the healthcare provider.
● Not abruptly stop taking Isosorbide Dinitrate without medical advice, as this may worsen angina.
● Stay aware of the possibility of developing tolerance toward the drug, which can reduce its effectiveness over time.

● Taken orally with or without food, as directed by a healthcare professional.
● The tablet should not be crushed or chewed for sustained-release formulations to maintain its extended-release properties.


● Patients with a history of hypersensitivity to nitrates should not use Isosorbide Dinitrate.
● Caution is advised in patients with severe anemia, hypotension, or those with a recent history of myocardial infarction.
● The medication should be used cautiously in pregnant or nursing women.

Drug Interactions:

● Isosorbide Dinitrate can have significant interactions with phosphodiesterase inhibitors (e.g., sildenafil), potentially leading to severe hypotension.
● Patients should inform their healthcare provider of all their medications to prevent adverse interactions

Side Effects

● Headache, which often diminishes with continued use.
● Dizziness or lightheadedness, especially when standing up quickly.
● Flushing or warmth in the face and neck.

Serious side effects that require medical attention include:

● A pronounced drop in blood pressure (hypotension).
● An increase in angina symptoms if the medication is abruptly discontinued.
● Tachycardia (rapid heart rate).


● Store Isosorbide Dinitrate at room temperature, away from light and moisture.
● Keep the medication in its original container and tightly closed.
● Isosorbide Dinitrate should be kept out of children's reach.

Special Precautions

Before taking Isosorbide Dinitrate, patients should inform their healthcare provider if they:

● Have any allergies to nitrates or other medications.
● Are suffering from conditions like hypothyroidism, malnutrition, or hypothermia.
● Are pregnant, planning to become pregnant, or breastfeeding.


Symptoms of an Isosorbide Dinitrate overdose may include severe dizziness, fainting, or an abnormally slow or rapid pulse. In the event of a suspected overdose, it is crucial to seek immediate emergency medical assistance.


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