Indications:
Lansoprazole is indicated for:
● Treatment of GERD, including erosive esophagitis and symptomatic relief of GERD.
● Healing of duodenal ulcers and the management of Zollinger-Ellison syndrome.
● Eradication of Helicobacter pylori, in combination with antibiotics, to reduce the risk of duodenal ulcer recurrence.
Patients are advised to:
● Adhere to the dosing instructions provided by their healthcare provider.
● Understand that it may be taken before meals for better efficacy.
● Know that long-term use may be associated with an increased risk of fractures, vitamin B12 deficiency, and magnesium deficiency.
Administration:
● Lansoprazole is available as delayed-release capsules or orally disintegrating tablets.
● It is typically taken once daily, before eating, unless directed otherwise by a healthcare provider.
Precautions:
● Individuals with a known hypersensitivity to lansoprazole or any other constituents of the formulation should avoid its use.
● Caution is advised in patients with a history of liver disease.
● Regular monitoring may be necessary for long-term users to check for vitamin B12 levels, magnesium levels, and bone density.
Drug Interactions:
● Lansoprazole can interact with drugs metabolized by the liver enzyme CYP2C19, altering their plasma levels.
● It may also reduce the absorption of drugs that require an acidic environment, such as ketoconazole, iron salts, and erlotinib.
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