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Lansoprazole targets the final step of acid production in the stomach, providing a more comprehensive suppression of gastric acid secretion compared to antacids and H2-receptor antagonists. Its ability to significantly reduce stomach acidity helps in the treatment of ulcers and minimizes the risk of their recurrence. Additionally, by lowering acid levels, lansoprazole assists in the relief of symptoms such as heartburn and acid reflux, improving patients’ quality of life.



Lansoprazole is a proton pump inhibitor (PPI) medication primarily used for treating and managing gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. By inhibiting the hydrogen/potassium ATPase enzyme system on the gastric parietal cell surface, lansoprazole effectively reduces gastric acid secretion. This action not only aids in alleviating symptoms associated with acid-related disorders but also promotes healing of the gastric mucosa, making it highly effective for long-term management of these conditions.

Additional information



Lansoprazole is indicated for:

● Treatment of GERD, including erosive esophagitis and symptomatic relief of GERD.
● Healing of duodenal ulcers and the management of Zollinger-Ellison syndrome.
● Eradication of Helicobacter pylori, in combination with antibiotics, to reduce the risk of duodenal ulcer recurrence.

Patients are advised to:

● Adhere to the dosing instructions provided by their healthcare provider.
● Understand that it may be taken before meals for better efficacy.
● Know that long-term use may be associated with an increased risk of fractures, vitamin B12 deficiency, and magnesium deficiency.


● Lansoprazole is available as delayed-release capsules or orally disintegrating tablets.
● It is typically taken once daily, before eating, unless directed otherwise by a healthcare provider.


● Individuals with a known hypersensitivity to lansoprazole or any other constituents of the formulation should avoid its use.
● Caution is advised in patients with a history of liver disease.
● Regular monitoring may be necessary for long-term users to check for vitamin B12 levels, magnesium levels, and bone density.

Drug Interactions:

● Lansoprazole can interact with drugs metabolized by the liver enzyme CYP2C19, altering their plasma levels.
● It may also reduce the absorption of drugs that require an acidic environment, such as ketoconazole, iron salts, and erlotinib.

Side Effects

● Headache
● Diarrhea
● Nausea
● Abdominal pain

Serious side effects that require immediate medical attention:

● Vitamin B12 deficiency
● Magnesium deficiency
● Clostridium difficile-associated diarrhea
● Bone fractures after long-term use


● Lansoprazole should be stored at room temperature, avoiding exposure to excessive heat and moisture. Keep the medication in its original container until it is time to take it.

Special Precautions

Before using lansoprazole, patients should inform their healthcare provider if they:

● Are pregnant, planning to become pregnant, or breastfeeding. The effects of lansoprazole on an unborn baby or a nursing infant are not well-established.
● Have been advised to take a magnesium supplement, as long-term use may lead to magnesium deficiency


Symptoms of a lansoprazole overdose may include confusion, drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, flushing, headache, and dry mouth. In the event of a suspected overdose, immediate medical attention is necessary to manage symptoms effectively.


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