Moclobemide belongs to the antidepressant category of drugs known as reversible inhibitors of monoamine oxidase A (RIMA). By selectively targeting and inhibiting the MAO-A enzyme, moclobemide leads to an increase in the availability of central nervous system neurotransmitters, playing a crucial role in mood regulation and anxiety disorders. This selective inhibition allows for a more favorable side effect profile compared to older, non-selective monoamine oxidase inhibitors (MAOIs), making Moclobemide a preferred choice in treating depression and anxiety.

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Moclobemide represents an essential medication within the class known as reversible inhibitors of monoamine oxidase A (RIMA), primarily utilized in the treatment of depression and social anxiety. Its pharmacological action involves selectively inhibiting the monoamine oxidase A enzyme, responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine, thereby increasing their levels in the brain and contributing to improved mood and anxiety reduction. This analysis delves deep into Moclobemide’s medicinal profile, including its therapeutic benefits, administration protocols, safety measures, potential side effects, drug interactions, and vital information for patients and healthcare providers.

Additional information



● Depression: Effective in alleviating symptoms of depression, including major depressive disorder.

● Social Anxiety Disorder (SAD): Used to reduce anxiety and fear associated with social interactions or performance situations.

Patient Guidelines

● For patients prescribed Moclobemide, adherence to the following guidelines is important to maximize therapeutic outcomes and ensure safety:

● Maintain consistency with the prescribed dosage and treatment schedule, refraining from any alterations unless advised by a healthcare professional.

● Be aware of and promptly report any adverse reactions to your healthcare provider.

● Take precautions when consuming foods high in tyramine (less stringent than other MAOIs, but caution is advised).

● To avoid potential drug interactions, provide a comprehensive list of all other medications and supplements being taken to the healthcare provider.

● Be watchful for signs of serotonin syndrome, a rare but serious condition, especially when Moclobemide is combined with other serotonergic drugs.

Administration Details

● Formulation: Available in oral tablet form.

● Dosage: Dosage and administration are determined based on the severity of the condition being treated, patient response, and tolerability. Typically, the starting dose is lower, which may be gradually increased. For depression, dosages range from 300 mg to 600 mg per day, divided into two doses.

Safety Precautions

● Pregnancy and Lactation: The safety of Moclobemide during pregnancy and breastfeeding is not well established. It should only be used when needed and after a risk-benefit analysis by a healthcare provider.

● Allergic Reactions: If symptoms of an allergic reaction, such as rash, itching/swelling, severe dizziness, or trouble breathing, occur, immediate medical attention should be sought.

Drug Interactions

Moclobemide requires careful management to avoid interactions with:

● Other antidepressants: Particularly SSRIs, to prevent serotonin syndrome.

● Sympathomimetic drugs (including common cold medications and nasal decongestants): May lead to hypertensive reactions.

● Tyramine-rich foods: While less restrictive than non-selective MAOIs, consuming large amounts of tyramine-containing foods can increase blood pressure.

Side Effects

● Dizziness
● Nausea
● Headache
● Insomnia
● Dry mouth
● Serious Side Effects

Immediate medical assistance is crucial if experiencing:

● Signs of serotonin syndrome (agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea).
● Severe skin reactions
● Elevated blood pressure


● Moclobemide should be stored at room temperature, in a dry place away from direct sunlight. It must be kept in its original packaging until used to protect it from moisture and keep it out of reach of children and pets.

Special Precautions

● Professional Supervision: Healthcare professionals must monitor patients, especially during the initial phases of treatment, to adjust dosages as needed and observe for adverse reactions.

● Informed Decision-Making: Patients should be equipped with comprehensive information regarding the benefits and risks of Moclobemide treatment, enabling them to play an active role in their treatment planning.


● Symptoms of overdose may include confusion, drowsiness, lethargy, and in severe cases, coma or convulsions. An overdose of Moclobemide requires immediate medical intervention, where supportive and symptomatic care will be administered.


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