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Xigduo acts synergistically through its components. Metformin reduces hepatic glucose production and improves insulin sensitivity, while dapagliflozin reduces renal glucose reabsorption, promoting glucose excretion via urine. This combined action helps lower blood sugar levels more effectively than either drug alone.
Xigduo, a combination oral medication consisting of dapagliflozin and metformin, is utilized in the management of type 2 diabetes. This medication combines the actions of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, which helps the kidneys eliminate glucose from the bloodstream, with metformin, which decreases glucose production in the liver and improves the body’s response to insulin.
| Usage | Indications: ● Type 2 Diabetes Mellitus: Xigduo is indicated in adults to improve glycemic control when treatment with both dapagliflozin and metformin is appropriate. Administration Guidelines Dosage: ● Xigduo is available in multiple strengths and the dosage is determined based on the patient's current regimen, effectiveness, and tolerability. Method of Administration: ● Oral: Xigduo is taken orally, usually twice daily with meals, which helps to reduce the gastrointestinal side effects commonly associated with metformin. Dosage Form: ● Coated Tablets: Xigduo is usually provided in the form of film-coated tablets. Safety Preclusions Pregnancy and Breastfeeding: ● Xigduo should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding due to the potential for adverse effects on the newborn. Drug Interactions: ● Care should be taken when used with diuretics or insulin as it may increase the risk of dehydration and severe changes in blood sugar levels. ● Patients should discuss their medicatio |
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| Side Effects | ● Nausea Serious Side Effects: In rare cases, serious side effects that require immediate medical attention may include: ● Lactic acidosis (a buildup of lactate in the blood) |
| Storage | ● Xigduo should be stored at room temperature, between 15°C and 30°C (59°F and 86°F). Tablets should be kept in their original package to protect them from humidity and light. |
| Special Precautions | ● Patients should be monitored for signs of dehydration and ketoacidosis, especially during illness or whenever experiencing severe stress. It's important to maintain adequate hydration while taking Xigduo. Regular follow-ups with a healthcare provider are essential to monitor kidney function and overall treatment efficacy. |
| Overdose | ● An overdose of Xigduo may result in lactic acidosis or the exacerbation of some side effects, such as hypoglycemia. Immediate medical attention is crucial for managing overdose symptoms. Treatment is supportive, depending on symptoms, as there is no specific antidote for dapagliflozin or metformin overdose. |
| MG | 5/1000mg, 5/850mg |
| Tablets | 60 Tablets |
