Depression is a complex condition and more often than not crippling, the consequences of which millions worldwide have to face. For those fighting against the most intense form of depression known as major depressive disorder (MDD) that are unable to experience any form of recovery through the use of traditional treatments, a medication known as Rexulti contains an active ingredient called brexpiprazole. Thus, this medication has been approved by the FDA to be taken in conjunction with other forms of antidepressants, Rexulti works in correspondence with these medications to help control TRD. This guide explores how Rexulti works, its pros and adverse side effects, and how it stacks up against other treatments. We will also highlight ways in which Better You Rx can provide access to this prescription medication affordably while ensuring quality care.
What is Rexulti and What is it Used For?
Rexulti is classified as an atypical antipsychotic and was initially approved in 2015 to treat schizophrenia. Since its approval, it has also been useful in treating MDD, especially in patients whose depression does not improve with other available antidepressants.
Such a medication is generally used in conjunction with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor in adults diagnosed with major depressive disorder who are treatment resistant. Because it acts on various neurotransmitter systems in the brain, it maintains a balance of mood, improves function in cognition, and reduces emotional extremes without sedation or emotional blunting. How Does Rexulti Work in the Brain?
Rexulti works by modulating both dopamine and serotonin receptors in the brain, which play critical roles in maintaining mood and cognition. Unlike most classical antidepressants, which only target the serotonin neurotransmitter level, Rexulti affects pathways for both dopamine and serotonin neurotransmitters.
As a partial agonist of the dopamine D2 and serotonin 5-HT1A receptors, Rexulti stabilizes mood, hence improving emotional responses, although it is an antagonist at serotonin 5-HT2A receptors. This unique mechanism of action helps reduce symptoms of depression, such as the following:
- Persistent sadness
- Lack of motivation
- Feelings of worthlessness or hopelessness
- Difficulty concentrating
Rexulti for Treatment-Resistant Depression
In the cases of many, especially those suffering from major depressive disorder, the use of standard treatments like SSRIs or SNRIs is not very beneficial. Treatment-resistant depression occurs when symptoms do not improve once medications are taken. In such a scenario, Rexulti could act as a much-needed respite by augmenting the efficacy of already prescribed antidepressants.
When used alongside a primary antidepressant, Rexulti improves mood and emotional bluntness, among other symptoms. Research has weighed in favor of the addition of Rexulti with other standard antidepressants to achieve faster symptom improvement and better functional outcomes.
Rexulti vs. Other Antidepressants and Antipsychotics
Against the background of other antidepressant treatments, including SSRIs and SNRIs, Rexulti has some distinct advantages. Traditional antidepressants usually act on serotonin, while Rexulti affects serotonin and dopamine, offering a wider symptom coverage.
Rexulti versus Abilify: Though both Rexulti and Abilify (aripiprazole) are used as adjunctive treatments for depression, Rexulti might offer faster symptom relief and a more balanced emotion regulation approach.
Common Side Effects of Rexulti
Like all other medications, Rexulti also has some potential side effects associated with its use. On the whole, it is considered to be well-tolerated as compared to the older varieties of antipsychotic medications. Some of the more common side effects include:
- Weight gain: There may be increased appetite with mild to moderate weight gain.
- Fatigue or drowsiness: A feeling of tiredness or sedation can be experienced, especially during the initial days of treatment.
- Restlessness or agitation: Akathisia may be a problem for some. Dizziness: A feeling of light-headedness. Increased appetite: Like weight gain, increased appetite can also occur. In rare cases, more serious side effects can include: Tardive dyskinesia: There is the development of involuntary muscle movements. High blood sugar: Symptoms of diabetes. Increased cholesterol: Monitoring may need to be performed on a regular basis. Low blood pressure: This may lead to dizziness, particularly when standing.
Due to this, it is very important to pay attention to side effects and communicate effectively with your doctor to ensure that the medication works and is well-tolerated.
How Long Does Rexulti Take To Work?
One of the most common questions about Rexulti is how long it takes to start working. While many patients begin to notice significant improvements after 2-4 weeks, it may take as long as 6-8 weeks to fully realize the benefits of this medication. Still, others may realize earlier relief with the addition of Rexulti to their current antidepressant.
However, you will still be in close contact with your health care provider to monitor your improvement and to ensure the treatment is unfolding as anticipated. If you are concerned about withdrawal symptoms from Rexulti, your health care provider will guide you through a proper tapering procedure if discontinuation is necessary.
Is Rexulti Addictive?
No, Rexulti is not addictive. It does not have the potential for abuse and dependence seen with controlled substances. However, you should take the drug as prescribed by the doctor and never suddenly stop the medication on your own. This is because sudden cessation of Rexulti can lead to the development of withdrawal symptoms or recurrence of depressive symptoms. At all times, you should be under the guidance of your healthcare professional when tapering off this medication safely.
Rexulti and Comorbidities
By using Rexulti, especially for those patients who have a co-occurring condition such as anxiety, mood swings, or irritability, a difference might be noticed. It effectively acts on both emotional and cognitive symptoms, and for this reason, the medication has become a great treatment option for patients who suffer from multiple mental health challenges all at once.
For example, Rexulti for mood swings helps balance extremes of emotions while its interaction with dopamine improves motivation and focus.
Where to Buy Affordable Rexulti
At Better You Rx, we understand how much it means for effective medications to become accessible. That is why at Better You Rx, we have Rexulti available at competitive prices, making sure those who need the medication could access it without breaking their wallet. We connect you with trusted suppliers on our platform so that you don’t have to jump through hoops to get the treatment you need. Take control of your health on your own terms-whether for you or your loved one.
Frequently Asked Questions (FAQs)
How long does it take before Rexulti starts working to improve one’s depression? Improvement of depression on this medication usually kicks in within 2-4 weeks, although the full effect may take up to 6-8 weeks.
Can Rexulti cause weight gain? Yes, one of the potential side effects of this medication is weight gain. If this is of concern, your healthcare provider can help you outline a plan to maintain or minimize weight gain.
Is Rexulti addictive or habit-forming? No, Rexulti is not addictive. However, regarding tapering off the medication, if necessary, it’s important to follow your doctor’s instructions.
Is Rexulti safe to use during pregnancy? Rexulti may affect the developing fetus, and you should consult your healthcare provider about the appropriateness of using Rexulti during pregnancy.
Conclusion: Is Rexulti Right for You?
Rexulti has been a godsend for people who suffer from major depression and for whom other antidepressants have not been effective. It is highly effective for managing resistant depression because it can tackle the imbalances of both dopamine and serotonin. Like with any other medication, it is important to work closely with your healthcare professional to find the right treatment approach.
If you’re seeking Rexulti for depression, Better You Rx can help make this treatment process easier for you so that you will have the best care and pricing. Start your path to wellness today; consult with your doctor to see if Rexulti may be the right choice for you.
