Avalide utilizes the complementary actions of its two components to manage hypertension. Irbesartan inhibits the effects of angiotensin II, which typically causes blood vessels to constrict, thereby lowering resistance to blood flow. On the other hand, hydrochlorothiazide increases the excretion of sodium and water, resulting in a reduced blood volume for the heart to pump, assisting in the reduction of blood pressure. The combination of an angiotensin II receptor antagonist with a diuretic can result in a more significant blood pressure decrease, beneficial for patients needing heightened control over their hypertension.

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Avalide is a prescription medication designed to treat hypertension (high blood pressure). It is a combination drug consisting of two active substances: irbesartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic. Irbesartan relaxes blood vessels, allowing blood to flow more easily, whereas hydrochlorothiazide helps the body get rid of excess salt and water, decreasing the blood volume. The combined action of these two drugs lowers blood pressure more effectively than when used alone.

Additional information


Avalide is taken orally, generally once per day, as prescribed by a healthcare professional. The proper dosage is determined based on the individual's response to the medication, other existing health conditions, and other medications the patient may be taking. The medication can be ingested with or without food. Commencing treatment typically requires caution, especially concerning dose adjustments, and regular monitoring of blood pressure and kidney functions is recommended due to the inclusion of a diuretic component.

Side Effects

● Dizziness or lightheadedness, particularly when getting up suddenly from a sitting or lying position ● Dehydration or electrolyte disturbances caused by increased urination ● Stomach pain, muscle cramps, or weakness Less common but serious side effects may include: ● Severe allergic reactions, such as rash or swelling of the face or throat ● Marked changes in kidney function, potentially leading to kidney failure ● Profound low blood pressure, particularly in individuals with reduced blood volume ● Increases in blood urea nitrogen and serum creatinine ● Significant changes in electrolytes, including potassium, sodium, and magnesium levels


Avalide tablets should be stored at room temperature, protected from light and moisture. They should remain in their original packaging, kept well-sealed, and stored safely away from children and pets. The storage instructions provided on the label or by the dispensing pharmacy should be followed carefully to ensure the medication's efficacy.

Special Precautions

Before commencing treatment with Avalide, patients should inform their healthcare provider about any existing medical conditions, particularly any history of kidney or liver disease, gout, lupus, or diabetes. All current medications, including over-the-counter drugs and dietary supplements, should be disclosed to prevent potential interactions. It is imperative to avoid dehydration, and patients on Avalide may need to be careful with the consumption of potassium-containing salt substitutes or supplements. Activities that require alertness, such as driving or using machinery, should be approached cautiously until the patient understands how the medication affects them. Avalide is not recommended for use during pregnancy due to possible harm to the unborn baby, especially in the second and third trimesters. Breastfeeding mothers should consult with their healthcare provider, as it is unknown if Avalide passes into breast milk.


An overdose of Avalide may lead to symptoms such as acute hypotension, electrolyte disturbances, dehydration, and decreased kidney function. In the event of an overdose, immediate medical attention is required. Supportive care in a hospital setting will involve monitoring and potentially correcting vital blood parameters, renal function, and imbalances in electrolytes


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