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Cytoxan (Cyclophosphamide)

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Cyclophosphamide, either alone or combined with other medications, is utilized to manage various conditions. These include Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (types of cancers that begin in white blood cells fighting infection); cutaneous T-cell lymphoma (CTCL, immune system cancers showing as skin rashes); multiple myeloma (a type of bone marrow cancer); and certain types of leukemia (cancer of white blood cells), encompassing chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

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Description

Cyclophosphamide, either alone or combined with other medications, is utilized to manage various conditions. These include Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (types of cancers that begin in white blood cells fighting infection); cutaneous T-cell lymphoma (CTCL, immune system cancers showing as skin rashes); multiple myeloma (a type of bone marrow cancer); and certain types of leukemia (cancer of white blood cells), encompassing chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Additionally, it treats retinoblastoma (eye cancer), neuroblastoma (nerve cell cancer mainly in children), ovarian cancer (female reproductive organ cancer), and breast cancer. Cyclophosphamide is also employed for nephrotic syndrome (kidney damage disease) in children whose condition has not improved, worsened, or recurred after using other medications, or for children who experienced intolerable side effects with prior medications. This medication falls within the alkylating agents class and exerts its effects by impeding the growth of cancer cells when used for cancer treatment. In the context of nephrotic syndrome, it suppresses the immune system.

Additional information

Usage

Usage
-Cyclophosphamide is administered in tablet form and is taken orally once a day. The duration of treatment hinges on the specific drugs used, your body's response, and the type of cancer or condition. Take it regularly at the same time each day. Adhere closely to the instructions on your prescription label, and seek clarification from your doctor or pharmacist if needed. Strictly follow the prescribed dosage, avoiding alterations without medical guidance. Your doctor may adjust your dose or treatment timeline based on your response and any encountered side effects. Keep an open dialogue with your doctor regarding your treatment experience and do not cease usage without consulting them.

Side Effects

Side Effects
Cyclophosphamide can lead to side effects. Inform your doctor if any of these symptoms become severe or persist:
• Nausea
• Vomiting
• Loss of appetite or weight
• Abdominal pain
• Diarrhea
• Hair loss
• Mouth or tongue sores
• Skin color changes
• Finger or toenail changes
Certain side effects can be serious. If you encounter any of the following, contact your doctor promptly:
• Soreness in the throat, fever, chills, or indications of infection
• Slow wound healing
• Unusual bleeding or bruising
• Black, tarry stools
• Painful urination or red urine
• Rash
• Hives
• Itching
• Difficulty breathing or swallowing
• Shortness of breath
• Cough
• Swelling in legs, ankles, or feet
• Chest pain
• Yellowing of skin or eyes
Cyclophosphamide may heighten the risk of other cancers. Discuss these risks with your doctor. If you experience any unusual issues while taking this medication, contact your doctor promptly.

Storage

Storage
-Store this medication in its original container, tightly sealed, and away from children. Keep it at room temperature, avoiding excessive heat and moisture (not in the bathroom). Dispose of unused medications safely to prevent accidental consumption by pets, children, or others. Please do not dispose of the medication by flushing it down the toilet. Opt for a medicine take-back program. Safeguard all medications from children's reach, as some containers aren't child-resistant. To prevent accidental ingestion, lock safety caps and place medications in a secure, elevated location.

Special Precautions

Special Precautions:
Before using cyclophosphamide:
• Inform your doctor and pharmacist about any allergies you have to cyclophosphamide, other alkylating agents like bendamustine (Treanda®), busulfan (Myleran®, Busulfex®), carmustine (BiCNU®, Gliadel® Wafer), chlorambucil (Leukeran®), ifosfamide (Ifex®), lomustine (CeeNU®), melphalan (Alkeran®), procarbazine (Mutalane®), or temozolomide (Temodar®), as well as any other medications or ingredients in cyclophosphamide. You can ask your pharmacist for a list of ingredients.
• Inform your doctor and pharmacist about all prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking or planning to take. Inform your doctor about any of the following medications: allopurinol (Zyloprim®), cortisone acetate, doxorubicin (Adriamycin®, Doxil®), hydrocortisone (Cortef®), or phenobarbital (Luminal® Sodium). Your doctor might need to modify your medication dosages or closely supervise you due to potential side effects. Many other medications can interact with cyclophosphamide, so share all your medication details with your doctor.
• Let your doctor know if you've previously undergone treatment with other chemotherapy medications or if you've had recent x-rays. Also, disclose any history of kidney or liver disease.
• Be aware that cyclophosphamide may impact women's menstrual cycles and halt sperm production in men. It can lead to permanent infertility, although assuming the inability to conceive or cause pregnancy is not advised. Pregnant or breastfeeding women should inform their doctors before starting this medication. Avoid planning to have children during chemotherapy or shortly after treatment (consult your doctor for specifics). Employ reliable birth control methods to prevent pregnancy as cyclophosphamide may harm the fetus.
• Inform your doctor or dentist about your use of cyclophosphamide if you're undergoing any type of surgery, including dental procedures.

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