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Avapro specifically targets the angiotensin II receptor type 1 (AT1), found in many tissues but primarily in the heart’s and blood vessels’ vascular smooth muscles. The inhibition of the AT1 receptor by irbesartan prevents angiotensin II from binding to it, resulting in vasodilation, reduced vasopressin secretion, and reduced aldosterone production and secretion. This series of actions leads to a decrease in blood pressure. By managing hypertension, Avapro reduces the risk of stroke, heart attack, and kidney problems, offering significant benefits for patients requiring long-term management of their blood pressure.
Avapro is a prescription medication designed to treat hypertension (high blood pressure) and to help protect the kidneys from damage due to diabetes. It contains the active substance irbesartan, which belongs to a class of drugs known as angiotensin II receptor antagonists. By blocking the action of angiotensin II, a powerful vasoconstrictor, irbesartan causes blood vessels to relax and widen, which lowers blood pressure and improves blood flow.
| Usage | Avapro is administered orally, with or without food, typically once per day. The dosage is determined based on the patient’s medical condition, response to treatment, and other medications they may be taking. To achieve the best effect, taking Avapro regularly and exactly as prescribed by a healthcare professional is essential. Adjustments to the dosage may be necessary based on the individual's blood pressure response, but such changes should only be made under medical supervision. |
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| Side Effects | ● Dizziness or light-headedness, particularly when standing up from a sitting or lying position ● Fatigue ● Nausea or upset stomach Less common but more serious side effects may include: ● A decrease in kidney function ● Hyperkalemia (high potassium levels in the blood) ● Swelling of the face, lips, tongue, or throat, which may indicate an allergic reaction ● Jaundice (yellowing of the skin or eyes) as a sign of liver damage |
| Storage | Store Avapro tablets at room temperature, away from light and moisture. It is critical to keep the medication in its original container, tightly closed, and out of reach of children and pets. To maintain its effectiveness and safety, follow the specific storage instructions on the medication’s label or package. |
| Special Precautions | Before starting treatment with Avapro, patients need to share their complete medical history with their healthcare provider, especially any records of kidney or liver disease, dehydration, electrolyte imbalances, or if they have had angioedema. Since Avapro can interact with other medications and substances, a comprehensive list of all medications, including over-the-counter drugs and supplements being taken, should be provided to the healthcare provider. Patients should know Avapro might cause dizziness, so caution is advised when driving or operating heavy machinery. Dehydration should be avoided, and consuming potassium-rich supplements or salt substitutes without medical advice is discouraged due to the risk of hyperkalemia. Pregnant women should not use Avapro, especially in the second and third trimesters, due to the risk of harm to the unborn baby. It is unknown if Avapro passes into breast milk, so breastfeeding mothers should consult their healthcare provider for advice. |
| Overdose | An overdose of Avapro may result in symptoms such as severe dizziness, fainting, or unusually slow or fast heartbeat. Should an overdose be suspected, immediate medical attention is necessary. Treatment for an overdose typically involves supportive care in a hospital setting where vital signs can be monitored, and any necessary adjustments to fluid and electrolyte balances can be made. |
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