Estradiol is biologically identical to the estrogen produced by the human ovaries. It is available under various brand names and comes in multiple forms, including oral tablets, topical creams, patches, injections, and vaginal rings. Its primary function in therapy is to replace or supplement natural estrogen levels in the body, which can decline due to menopause, ovarian failure, or certain medical procedures like oophorectomy. By mimicking the action of natural estrogen, estradiol can alleviate various symptoms and conditions associated with low estrogen levels.

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Estradiol is a form of estrogen, a primary female sex hormone. It is used in various hormone therapy treatments to manage symptoms associated with menopause, such as hot flashes, vaginal dryness, and irritation. Furthermore, it plays a role in the treatment of conditions like hypoestrogenism, atrophic vaginitis, and as part of some cancer treatment protocols. Estradiol can also help prevent osteoporosis in postmenopausal women, highlighting its versatility in addressing multiple health concerns related to estrogen deficiency.

Additional information



● Menopausal Symptoms: Treatment of hot flashes, night sweats, vaginal dryness, and irritation.
● Hypoestrogenism: Management of low estrogen levels due to the ovaries not producing enough estrogen.
● Atrophic Vaginitis: Treating the thinning, drying, and inflammation of the vaginal walls during menopause.
● Osteoporosis Prevention: In postmenopausal women, to prevent bone loss and reduce the risk of fractures.
● Specific Cancers: This is part of the treatment protocol for certain cancers that respond to hormones, such as some types of breast cancer.

Administration Guidelines:

The method of administration can vary:

● Oral tablets: Usually taken once daily.
● Topical creams/gels: Applied according to the product instructions, varying from once daily to once weekly.
● Patches: Applied to the skin, typically changed once or twice a week.
● Vaginal rings: Inserted into the vagina, typically replaced every three months.
● Injections: Administered by a healthcare professional at prescribed intervals.

Side Effects

● Nausea
● Breast tenderness
● Headache
● Swelling of ankles/hands (fluid retention)
● Weight changes
● Abdominal cramping or bloating

More severe side effects that require immediate medical attention include:

● Unusual vaginal bleeding
● Increased blood pressure
● Liver disorders (dark urine, yellowing eyes/skin)
● Blood clots (pain in the chest, legs, sudden shortness of breath, vision changes)


Storage directions can vary based on the formulation. Generally, estradiol products should be stored at room temperature, away from light and moisture. Patches and other forms must be kept in their original packaging until use. Always refer to the specific product labeling for storage requirements.

Special Precautions

Before using estradiol, communicate to your healthcare provider if you have:

● A history of hormone-related cancer
● Liver disease
● Risk factors for cardiovascular disease (such as smoking, high blood pressure)
● History of blood clots
● Endometriosis or uterine fibroid history


Symptoms of an overdose may include severe nausea, vomiting, and vaginal bleeding. In case of overdose, seek immediate medical attention.




100 Tablets


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