Glyburide exerts its hypoglycemic action primarily by stimulating the beta cells of the pancreatic islets of Langerhans to release insulin, thus enhancing the overall secretion of insulin from the pancreas. It is more applicable for individuals with some remaining pancreatic beta-cell function. The initiation of insulin release is dependent upon functioning beta cells in the pancreatic islets.

SKU: N/A Category:


Glyburide, also known by its brand names, such as Diabeta and Glynase, is a medication used to manage blood sugar levels in people with type 2 diabetes mellitus. As a part of the sulfonylurea class of drugs, glyburide works by increasing the release of insulin from the pancreas. This action helps lower blood sugar levels. It is used when diet, exercise, and weight reduction have not been found to control blood sugar well enough on their own.

Additional information


Glyburide is indicated for:

● Management of type 2 diabetes mellitus when diet, exercise, and weight reduction alone have not been able to control blood sugars.

Patients are advised to:

● Follow the prescribed dosage schedule carefully.
● Monitor their blood sugar levels regularly as directed by their healthcare provider.
● Continue following a diabetic diet and exercise program along with taking Glyburide.


● Glyburide may cause hypoglycemia, especially if used in conjunction with other antidiabetic medications, alcohol, or if meals are skipped.
● Liver and kidney function tests should be monitored periodically due to metabolism and excretion pathways.
● Caution is advised for the elderly or those with liver or kidney impairment as they may be more sensitive to its effects.
● Avoid excessive alcohol consumption as it may increase the risk of hypoglycemia or lead to a delayed recovery from hypoglycemia.

Side Effects

● Hypoglycemia (low blood sugar levels).
● Gastrointestinal disturbances such as nausea, heartburn, and fullness.
● Weight gain due to its insulin-secreting action.

More serious but less common side effects requiring medical attention:

● Severe hypoglycemia with symptoms such as extreme weakness, blurred vision, perspiration, tremors, trouble speaking, confusion, and seizures.
● Jaundice or liver dysfunction.
● Hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.


● Store Glyburide at room temperature, away from light and moisture.
● Do not store it in the bathroom.
● Keep all medications away from children and pets.

Special Precautions

Before using Glyburide, inform your healthcare provider if:

● You have a history of kidney or liver disease, thyroid disease, certain hormonal conditions, electrolyte imbalance, or a deficiency in G6PD.
● You are taking other medications, as Glyburide can interact with many drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), other oral antidiabetic medications, certain hypertension drugs, and anticoagulants.
● You are pregnant, planning to become pregnant, or breastfeeding. Glyburide can cross the placenta and may not be the preferred choice for diabetes management during pregnancy.


Symptoms of a Glyburide overdose are mainly hypoglycemic symptoms that may range from hunger, nausea to severe confusion, convulsions, or unconsciousness. Management involves prompt correction of hypoglycemia with oral carbohydrates, glucagon administration, or intravenous glucose, depending on the severity and responsiveness of the patient. Immediate medical attention is required.


2.5 MG, 5MG


100 Tablets


There are no reviews yet.

Be the first to review “Glyburide”

Your email address will not be published. Required fields are marked *