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Bosulif (Bosutinib Monohydrate)


Bosutinib is employed in the management of a specific form of chronic myeloid leukemia (CML), a type of cancer affecting white blood cells. It proves beneficial for individuals who have exhausted the benefits of alternative CML treatments or are unable to tolerate their side effects



Bosutinib is employed in the management of a specific form of chronic myeloid leukemia (CML), a type of cancer affecting white blood cells. It proves beneficial for individuals who have exhausted the benefits of alternative CML treatments or are unable to tolerate their side effects. Classified as a kinase inhibitor, Bosutinib operates by inhibiting the function of an aberrant protein that stimulates the proliferation of cancer cells. This mechanism effectively curbs the proliferation and dissemination of cancerous cells.

Additional information


-Bosutinib is administered in tablet form for oral consumption. Typically, it is taken once a day with a meal. Adhere to a consistent schedule, taking it around the same time daily. Carefully follow the instructions on your prescription label and seek clarification from your doctor or pharmacist for any unclear aspects. Ensure precise adherence to the prescribed dose, avoiding overuse or underuse. Consume the tablets as a whole, refraining from splitting, chewing, or crushing them. In case tablets are broken or crushed, avoid direct contact with your bare hands. Dosing adjustments may occur as per your treatment response and encountered side effects, which your doctor will determine. Regularly communicate your well-being during treatment. Even if you feel well, continue taking bosutinib. Discontinuation should only occur after consulting your doctor. Obtain a copy of the manufacturer's patient information from your pharmacist or doctor.

Side Effects

Side Effects
Bosutinib may lead to certain side effects. If you encounter any of these symptoms, inform your doctor, particularly if they are severe or persistent:
• Headache
• Loss of appetite
• Fatigue or weakness
• Back, joint, limb, or muscle pain
• Changes in taste perception
• Ringing in the ears
Certain side effects require prompt attention. Promptly get in touch with your doctor if you encounter any of the following:
• Nausea
• Vomiting
• Diarrhea
• Sudden abdominal pain
• Unexplained bleeding or bruising
• Blood in urine or stool
• Dizziness
• Fever, sore throat, chills, or signs of infection
• Shortness of breath and persistent cough
• Chest pain
• Enlargement of the face, hands, ankles, feet, or lower legs
• Rapid weight gain
• Yellowing of the skin and eyes
• Dark or tea-colored urine
• Hives
• Rash
• Itching
• Difficulty in breathing or swallowing
Bosutinib might also lead to other side effects. If you encounter any unusual problems while taking this medication, contact your doctor.


-Ensure proper storage of this medication by keeping it in its original container, tightly closed, and away from children. Store it at room temperature, avoiding excessive heat and moisture (not in the bathroom). Proper disposal is important; do not flush it down the toilet. Instead, utilize a medicine take-back program. If unavailable, consult your pharmacist or local garbage/recycling department. Safeguard all medications from children's access by using child-resistant containers and placing them out of reach and sight. For their safety, always secure safety caps and store medications in a secure location.

Special Precautions

Special Precautions
Before initiating bosutinib:
• Disclose any allergies to bosutinib or its ingredients to your doctor and pharmacist. Obtain a list of these ingredients from your pharmacist.
• Inform your doctor and pharmacist about all prescription and non-prescription medications, vitamins, supplements, and herbal products you take or intend to take. Mention any of the following: antifungal drugs like fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); aprepitant (Emend); bosentan (Tracleer); certain HIV medications such as amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); stomach acid reducers like esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); certain seizure medications like carbamazepine (Tegretol), phenobarbital (Luminal), and phenytoin (Dilantin); ciprofloxacin (Cipro, Proquin XR); clarithromycin (Biaxin); digoxin (Digitek, Lanoxin); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); modafinil (Provigil); nafcillin (Unipen, Nallpen); nefazodone; rifabutin (Mycobutin); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); telaprevir (Incivek); telithromycin (Ketek); and verapamil (Calan, Isoptin, Verelan). Many other medications may also interact with bosutinib, so inform your doctor of all medications, even if not listed here.
• If you're taking antacids like aluminum hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums), or a combination of calcium carbonate and magnesium (Rolaids), or acid-reducing meds like cimetidine (Tagamet), famotidine (Pepcid), or ranitidine (Zantac), take them 2 hours before or after bosutinib.
• Notify your doctor of any herbal products you use, especially St. John's wort.
• Discuss any history of liver or heart disease with your doctor.
• Inform your doctor if you are pregnant or intend to become pregnant. Do not conceive while on bosutinib; utilize effective birth control during treatment and for a month afterward. Consult your doctor about suitable birth control methods. If you become pregnant while on bosutinib, contact your doctor, as it may harm the fetus.
• Inform your doctor if you are breastfeeding. Avoid breastfeeding while taking bosutinib.


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