Creon (Pancrelipase)


Creon medication aids in the digestion of fats, proteins, and sugars. It comprises a blend of lipase, protease, and amylase, which are enzymes naturally produced by the pancreas to facilitate digestion.

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Creon medication aids in the digestion of fats, proteins, and sugars. It comprises a blend of lipase, protease, and amylase, which are enzymes naturally produced by the pancreas to facilitate digestion. Insufficient enzyme production in the body can result from various factors such as cystic fibrosis, chronic pancreatic inflammation, or pancreatic duct blockage. Creon can help compensate for the enzyme deficiency caused by these conditions.

Additional information


Creon is available as a delayed-release capsule to be taken orally with a meal or snack.
Please follow your prescription label instructions meticulously when using this medication. Adhere to your doctor's recommended Creon dosage; do not exceed or decrease it.
Avoid retaining the contents of a Creon capsule in your mouth, as this can lead to irritation.
Additionally, refrain from inhaling the powder from a Creon capsule or allowing it to come into contact with your skin, as it may irritate your nasal passages, lungs, and skin.
If necessary, you can open the capsule and sprinkle the contents into pudding or applesauce. Swallow the mixture immediately without chewing it, and do not save any leftover mixture.
The contents of a Creon capsule should be ingested promptly after opening. Dispose of any unused medication.
Do not crush or chew Creon capsules.
Pancrelipase is available under brand names other than Creon. Do not switch to a different brand without consulting your healthcare provider.
Consistent use of Creon yields the best results. Ensure you refill your prescription before running out of medication.

Side Effects

Side Effects
Common Side Effects of Creon
Please inform your doctor if any of the following side effects persist or worsen:
• Headache
• Cough or sore throat
• Dizziness
• Nausea or upset stomach
• Nosebleed
• Neck pain
• Experiencing a sensation of fullness after consuming a small quantity of food.
• Constipation
• Diarrhea
• Greasy stools
• Heartburn
• Gas
• Sore mouth or tongue
• Irritation around the rectum
• Weight loss
Serious Side Effects of Creon
Notify your doctor immediately if you encounter any of the subsequent serious side effects:
• Signs of an allergic reaction, which may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat.
• Hoarseness
• Severe nausea or vomiting
• Severe or unusual abdominal pain
• Difficulty with bowel movements
• Pain or swelling in your joints, particularly in your big toe


Please adhere to the following storage and disposal instructions for this medication:
• Keep it stored in its original container, ensuring the cap is tightly sealed, and place it out of reach of children.
• Store it at room temperature, avoiding exposure to excessive heat and moisture (refrain from storing it in the bathroom).
• If the medication container includes a desiccant (drying agent), do not remove it.
For the safe disposal of any unused medication and to prevent unintentional consumption by children, pets, or others, please follow these guidelines:
• Avoid flushing the medication down the toilet when disposing of it.
• Consider participating in a medication take-back program, which you can discuss with your pharmacist or local garbage/recycling department.
Since certain medication containers, such as weekly pill organizers, eye drop bottles, cream tubes, patches, and inhalers, may not be child-resistant and can be easily opened by young children, it is essential to:
• Always secure safety caps.
• Store the medication in a secure location that is elevated and out of children's sight and reach.


Before initiating Creon, please inform your doctor if you have a history of or current conditions related to:
• Diabetes
• Gout or elevated levels of uric acid in the blood
• Prior intestinal surgery
• Intestinal blockage, thickening, or scarring
• Cancer
• Kidney disease
• Lactose intolerance
• Difficulty swallowing capsules
• Allergic reactions to medications
Notably, Creon is derived from the pig pancreas. If you have an allergy to pork products, kindly notify your doctor.
While it is theoretically possible to contract a viral infection from pig-derived products, no such cases have been reported with Creon.
Creon may slightly increase the risk of developing a rare bowel disorder known as fibrosing colonopathy. Adhering to your doctor's prescribed dosage instructions can mitigate this risk.
Avoid taking Creon if you are experiencing sudden pancreatitis or a worsening of pancreatic issues.
Your doctor may recommend a specific dietary plan while on this medication. Make sure to adhere to these instructions carefully.
Pregnancy and Creon
The potential effects of Creon on unborn infants remain unknown.
Inform your doctor if you are pregnant or planning to conceive while using this medication.
Additionally, it is uncertain whether Creon can pass into breast milk or pose a risk to nursing infants.
Before using this medication while breastfeeding, consult with your doctor for guidance.


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