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Inlyta (Axitinib)


Axitinib is prescribed to manage advanced renal cell carcinoma (RCC), a form of kidney cancer that hasn’t responded to prior treatments. Axitinib falls under the category of kinase inhibitors, obstructing an aberrant protein’s signaling, which drives the multiplication of cancer cells.



Axitinib is prescribed to manage advanced renal cell carcinoma (RCC), a form of kidney cancer that hasn’t responded to prior treatments. Axitinib falls under the category of kinase inhibitors, obstructing an aberrant protein’s signaling, which drives the multiplication of cancer cells. This action aids in reducing or halting the spread of cancerous cells.

Additional information


-Axitinib is available in tablet form for oral administration. Typically, it is taken twice daily, with or without food, at roughly 12-hour intervals. Adhere meticulously to the instructions on your prescription label, and seek clarification from your doctor or pharmacist for any uncertainties. Take axitinib precisely as prescribed; avoid altering the dosage or frequency without your doctor's guidance. Swallow the tablets whole with a glass of water; do not break, chew, or crush them. If vomiting occurs after taking axitinib, refrain from taking an additional dose. Maintain your regular dosing routine.
Your doctor may initiate treatment with a low axitinib dose and gradually raise it, but no more frequently than once every 2 weeks. This adjustment hinges on your response to the medication and any potential side effects. Keep an open dialogue with your doctor regarding your treatment experience. Even if you feel well, continue taking axitinib as directed. Do not cease treatment without consulting your doctor. You can request a copy of the manufacturer's patient information from your pharmacist or doctor.

Side Effects

Side Effects
Axitinib may lead to side effects. Inform your doctor if any of the following symptoms persist or become severe:
• Diarrhea
• Reduced appetite or changes in taste perception
• Weight loss
• Nausea
• Vomiting
• Constipation
• Fatigue
• Weakness
• Voice alterations
• Skin issues like redness, pain, swelling, numbness, tingling, itching, or peeling on hands and feet
• Cough
• Joint or muscle pain
• Mouth sores
• Stomach discomfort
• Heartburn
• Headache
• Dizziness
• Rash
• Itching
• Dry skin
• Temperature sensitivity
• Pale skin
• Rapid heartbeat
• Hair loss
• Ringing in the ears
• Thirst
• Hemorrhoids
• Non-healing wounds or cuts
Certain side effects require immediate medical attention:
• Severe stomach pain
• Shortness of breath
• Unusual bleeding or bruising
• Black, tarry stools
• Red blood in stools
• Bloody vomit
• Coffee-ground-like vomit
• Chest pain or pressure
• Pain in arms, back, neck, or jaw
• Swelling, tenderness, warmth, or redness in a leg
• Abrupt onset of numbness or muscle weakness, notably affecting one side of the body, such as the face, arm, or leg.
• Sudden confusion, speech difficulties, or trouble understanding
• Acute vision disturbances occurring suddenly in either one or both eyes.
• Sudden challenges with walking, accompanied by dizziness or a loss of balance and coordination.
• Sudden severe headache without known cause
• Seizures
• Vision loss
Axitinib may produce other side effects. Contact your doctor if you encounter any unusual issues while taking this medication.


Please follow these storage and disposal guidelines for your medication:
• Keep the medication in its original container, securely sealed, and out of children's reach.
• Store it at room temperature, away from excessive heat and moisture (not in the bathroom).
• Dispose of any unneeded medication safely to prevent accidental ingestion by pets, children, or others.
• Do not flush this medication down the toilet; opt for a medicine take-back program instead.
• For information on local take-back programs, consult your pharmacist or contact your municipal waste/recycling department.
• Ensure that all medications are stored out of children's sight and reach, as many containers are not child-resistant and can be easily opened.
• To prevent accidental ingestion, always secure safety caps and place medications in a secure, elevated location, hidden from children's view and access.

Special Precautions

Special Precautions:
Before commencing axitinib treatment, please communicate the following to your doctor and pharmacist:
• Any allergies to axitinib, other medications, or ingredients in axitinib tablets. You can request a list of ingredients from your pharmacist.
• All prescription and non-prescription medications, vitamins, and nutritional supplements you currently use or intend to use. Specifically, mention:
• Medications such as bosentan (Tracleer), carbamazepine (Carbatrol, Epitol, Tegretol), clarithromycin (Biaxin, in Prevpac), itraconazole (Sporanox), ketoconazole (Nizoral), and medications for HIV/AIDS like atazanavir (Reyataz), efavirenz (Sustiva, in Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase), modafinil (Provigil), nafcillin, nefazodone, phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifamate, Rifater), rifapentine (Priftin), steroid medications like dexamethasone (Decadron), telithromycin (Ketek), and voriconazole (Vfend).
• It's important to note that many other medications can also interact with axitinib, so disclose all medications, even if not listed here.
• Inform your healthcare provider about any herbal supplements you are currently taking, with particular attention to St. John's wort.
• If you have a non-healing wound, or a history of bleeding problems, blood clots, high blood pressure, heart attack, gastrointestinal bleeding, brain cancer, pulmonary embolism, stroke or ministroke (TIA), or heart, liver, or thyroid conditions.
• Your pregnancy status or plans, and whether you intend to father a child. Axitinib can harm a fetus, so effective birth control is essential during treatment. Consult your doctor for suitable birth control methods. If pregnancy occurs while taking axitinib, inform your doctor.
• If you are breastfeeding.
• If you have upcoming surgery, including dental procedures, notify the healthcare provider at least 24 hours before, and follow your doctor's instructions regarding discontinuing axitinib.


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