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Inqovi (Cedazuridine / Decitabine)

$112.99

The combination of decitabine and cedazuridine is utilized to treat specific forms of myelodysplastic syndrome (conditions characterized by irregular blood cell production in the bone marrow, resulting in insufficient healthy blood cells), including chronic myelomonocytic leukemia (CMML) in adults.

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Description

The combination of decitabine and cedazuridine is utilized to treat specific forms of myelodysplastic syndrome (conditions characterized by irregular blood cell production in the bone marrow, resulting in insufficient healthy blood cells), including chronic myelomonocytic leukemia (CMML) in adults. Decitabine belongs to the class of medications known as hypomethylation agents, which stimulate the bone marrow to produce normal blood cells and eliminate abnormal ones in the marrow. Cedazuridine, categorized as a cytidine deaminase inhibitor, enhances the concentration of decitabine in the body, amplifying the medication’s therapeutic effectiveness.

Additional information

Usage

Usage:
The combination of decitabine and cedazuridine is provided in tablet form for oral administration. Typically, it's taken on an empty stomach during the first 5 days of a 28-day cycle. A crucial aspect is refraining from eating for 2 hours before and after each dose. Your doctor may recommend repeating the 28-day cycle, gauging your body's response. Typically, treatment spans a minimum of 4 cycles and may continue based on your doctor's assessment.
Ensure to swallow the tablets whole, refraining from splitting, chewing, or crushing them. In case of vomiting after taking the medication, do not take an additional dose; stick to your regular dosing schedule.
Your doctor will provide anti-nausea medication before each dose to prevent nausea and vomiting.
Depending on your experience of side effects, your doctor may adjust your dosage or temporarily/permanently halt treatment. It's crucial to communicate your well-being and any concerns during your decitabine and cedazuridine treatment.
For comprehensive information, consult the manufacturer's patient information provided by your pharmacist or doctor.

Side Effects

Side Effects:
Decitabine and cedazuridine may lead to side effects. If you encounter any persistent or worsening symptoms, notify your physician:
1. Fatigue
2. Paleness
3. Constipation
4. Diarrhea
5. Nausea
6. Vomiting
7. Stomach pain
8. Weight loss
9. Loss of appetite
10. Joint or muscle pain
11. Dizziness
12. Difficulty sleeping
13. Painful mouth sores or lip/tongue sores
14. Swelling in hands, feet, ankles, legs, or stomach
15. Tingling, numbness, or pain in hands or feet
Certain side effects may be serious. If you experience any of the following symptoms, contact your doctor immediately or seek emergency medical attention:
1. Fever, chills, cough, body aches, or signs of infection
2. Unusual bleeding, nosebleeds, or bleeding gums
3. Rapid or pounding heartbeat
4. Shortness of breath
5. Rash
Should you encounter any unusual issues while taking this medication, don't hesitate to reach out to your doctor.

Storage

Storage:
To maintain the efficacy of Inqovi and ensure its safety, store it in the original container, tightly sealed. Keep it at room temperature, away from excess heat and moisture (avoid bathroom storage). Safeguard it out of reach of children and pets. Do not flush unused medication; follow recommended disposal guidelines.

Special Precautions

c:
Before initiating decitabine and cedazuridine treatment:
1. Inform your doctor and pharmacist about any allergies to decitabine, cedazuridine, other medications, or ingredients in the tablets. Inquire with your pharmacist to obtain a list of the ingredients.
2. Disclose all prescription and non-prescription medications, vitamins, supplements, and herbal products you are taking or planning to take. Your doctor may need to adjust doses or monitor potential side effects.
3. Mention any history of kidney or liver disease to your doctor.
4. If you are female, discuss your pregnancy plans with your doctor. You may need a pregnancy test before starting treatment and must use birth control throughout treatment and for at least 6 months after your final dose. If you are male, both you and your female partner should use effective birth control while taking decitabine and cedazuridine and for 3 months after your final dose. If pregnancy occurs during treatment, contact your doctor.
5. If breastfeeding, refrain from doing so while taking decitabine and cedazuridine and for 2 weeks after your final dose.
6. Be aware that this medication may reduce male fertility. Discuss potential risks with your doctor.
7. If you have surgery, including dental procedures, inform the healthcare provider about your use of decitabine and cedazuridine.

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