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Koselugo (Selumetinib Sulfate)

$12,500.00

Koselugo (Selumetinib sulfate) is a prescription medication primarily used to treat children aged 2 years and older diagnosed with neurofibromatosis type 1 (NF1). It targets plexiform neurofibromas that cannot be entirely removed through surgical means.

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Description

Koselugo (Selumetinib sulfate) is a prescription medication primarily used to treat children aged 2 years and older diagnosed with neurofibromatosis type 1 (NF1). It targets plexiform neurofibromas that cannot be entirely removed through surgical means. This medication plays a vital role in managing this rare genetic condition by addressing the growth of these tumors. Please note that Koselugo’s safety and effectiveness in children under the age of 2 have not been established.

Additional information

Usage

Usage:
Selumetinib is administered in capsule form and should be taken orally. Here are the recommended steps:
• Take selumetinib twice daily, ideally on an empty stomach. Ensure there's a 2-hour gap before and a 1-hour gap after each dose without food. Try to maintain approximately 12-hour intervals between doses.
• Follow your prescription label's instructions meticulously, and don't hesitate to seek clarification from your doctor or pharmacist if any details are unclear. It's crucial to adhere to the prescribed regimen—neither exceed nor reduce the dose and avoid taking it more frequently than directed.
• Swallow the capsules whole with water, refraining from opening, chewing, or crushing them.
• If you happen to vomit after taking selumetinib, there's no need to take an additional dose. Stick to your regular dosing schedule.
• Communicate openly with your doctor about your treatment experience. They may adjust your dosage or consider temporary or permanent discontinuation of treatment if specific side effects occur.
• For additional information tailored to patients, consult your pharmacist or doctor for a copy of the manufacturer's patient information. This resource can provide valuable insights into your medication.

Side Effects

Side Effects:
Selumetinib may lead to side effects. If you experience any of the following symptoms, inform your doctor, especially if they are severe or persistent:
• Vomiting
• Constipation
• Stomach pain
• Nausea
• Dry skin
• Headache
• Mouth ulcers
• Itching
• Redness around the fingernails
• Nosebleeds
• Fatigue
• Loss of appetite
• Hair loss or alterations in hair color
Certain side effects require immediate medical attention. If you notice any of the following symptoms, contact your doctor promptly or seek emergency medical care:
• Fever
• Unusual bleeding
• Pale skin or excessive tiredness
• Blurry eyesight, vision loss, the appearance of dark spots in your vision, or any other alterations in your vision
• Diarrhea
• Rash, skin blisters, or peeling
• Muscle pain, weakness, or aches, or dark urine
• Coughing, wheezing, shortness of breath, swelling of the ankles and feet, or extreme tiredness
Selumetinib may also cause other side effects not listed here. If you encounter any unusual issues while taking this medication, reach out to your doctor for guidance.

Storage

Storage:
Store this medication in its original container, securely closed, and away from children. Keep it at room temperature, avoiding excess heat and moisture (do not store it in the bathroom). Retain the desiccant (small moisture-absorbing packet) in the bottle.
Protect children from potential harm by keeping all medications out of their sight and reach. Many containers, including those for eye drops, creams, patches, and inhalers, are not child-resistant and can be easily opened by young children. To prevent accidental poisoning, always secure safety caps and promptly store medications in a safe location that is inaccessible to children.
Dispose of any unused medications properly to prevent accidental consumption by pets, children, or others. Do not flush this medication down the toilet. Instead, utilize a medicine take-back program. Consult your pharmacist or contact your local garbage/recycling department to inquire about available take-back programs in your community.

Special Precautions

Special Precautions:
Before starting selumetinib treatment, it's essential to communicate the following information to your doctor and pharmacist:
• Any known allergies to selumetinib, other medications, or any components in selumetinib capsules. Request a list of ingredients from your pharmacist if needed.
• A comprehensive list of all prescription and nonprescription medications, vitamins, supplements, and herbal products you are taking or intend to take. Highlight medications like blood thinners, antifungals, corticosteroids, HIV medications, and others, as they may interact with selumetinib. Your doctor may need to adjust dosages or monitor you for potential side effects.
• Mention any herbal products you use, especially St. John's wort.
• Provide your medical history, including any vision problems, difficulty swallowing, or heart/liver conditions.
• If you are pregnant, planning pregnancy, or considering fathering a child, your doctor needs to know. Female patients should undergo a pregnancy test before beginning treatment and use contraception throughout the treatment period and for at least one week after the final dose. Male patients and their partners should also use birth control during treatment and for one week following the last dose. If pregnancy occurs during selumetinib treatment, contact your doctor immediately, as selumetinib may pose risks to the fetus.
• If you are breastfeeding, refrain from doing so while taking selumetinib and for one week after completing treatment.
Open and honest communication with your healthcare provider is essential for your safety and effective treatment. Your doctor will use this information to ensure your well-being and provide the best possible care.

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