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Lonsurf (Tipiracil Hydrochloride / Trifluridine)

Original price was: $5,612.78.Current price is: $5,602.78.

The blend of trifluridine and tipiracil is employed in the treatment of colon or rectal cancer that has metastasized to other areas of the body, especially in individuals previously treated with other chemotherapy drugs or unable to tolerate them.



The blend of trifluridine and tipiracil is employed in the treatment of colon or rectal cancer that has metastasized to other areas of the body, especially in individuals previously treated with other chemotherapy drugs or unable to tolerate them. Trifluridine belongs to the thymidine-based nucleoside analogs class and halts the proliferation of cancer cells. Tipiracil, a thymidine phosphorylase inhibitor, prolongs the effectiveness of trifluridine by slowing its breakdown in the body.

Additional information


The combination of trifluridine and tipiracil is administered in tablet form, and taken orally. Typically, it is taken twice daily, within one hour after breakfast and dinner, for five consecutive days, followed by a two-day break. This dosing pattern repeats and includes a two-week pause, constituting a 28-day cycle. The duration of this regimen depends on your response to the medication and any side effects you encounter. Maintain a consistent schedule for taking trifluridine and tipiracil, following your prescription label meticulously. Take the tablets exactly as prescribed by your doctor; do not exceed or reduce the dosage or alter the frequency without consulting your healthcare provider. Trifluridine and tipiracil tablets come in two distinct strengths, and your doctor may recommend a combination of both to achieve your prescribed dose. Familiarize yourself with the appearance of each tablet type and the quantity of each to take. If you have any uncertainties, seek guidance from your doctor or pharmacist. Your doctor may adjust your treatment or reduce the dose of trifluridine and tipiracil based on the side effects you encounter. Keep your doctor informed about how you're feeling during your treatment, and refrain from discontinuing the medication without consulting them. After handling trifluridine and tipiracil tablets, remember to wash your hands. If someone else is handling these tablets for you, ensure they wear rubber or latex gloves to prevent direct contact with the tablets. You can request a copy of the manufacturer's patient information from your pharmacist or doctor.

Side effects

Side effects

Trifluridine and tipiracil may lead to side effects. If any of the following symptoms are severe or persistent, inform your doctor:
1. Hair loss
2. Altered taste perception
3. Reduced appetite
4. Mouth sores or oral swelling
5. Fatigue
6. Excessive tiredness
Certain side effects require immediate medical attention. Get in touch with your doctor or seek immediate medical assistance if you encounter:
1. Fever, body aches, chills, or signs of infection
2. Severe or persistent nausea, vomiting, diarrhea, or abdominal pain
3. Weakness or breathlessness during physical activity
4. Paleness of the skin
5. Chest pain
6. Pain when taking deep breaths
7. Coughing up blood
8. Unusual bleeding or bruising
Trifluridine and tipiracil may also produce other side effects. Consult your doctor if you encounter any unusual issues while taking this medication.


Store this medication in its original container, securely closed, and out of children's reach. Keep it at room temperature, away from excess heat and moisture (avoid storing it in the bathroom). If you've removed tablets from their original container, dispose of any unused tablets after 30 days. Unneeded medications should be discarded properly to prevent accidental ingestion by pets, children, or others. Do not flush this medication down the toilet. Instead, utilize a medicine take-back program. Contact your pharmacist or local garbage/recycling department to inquire about available take-back programs in your area. It's vital to safeguard all medications from children, as various containers (including weekly pill organizers, eye drop bottles, creams, patches, and inhalers) may not be child-resistant, making them easy for young children to open. To prevent accidental poisoning in young children, always use safety caps and store medications in a secure location that is out of their reach and sight.

Special Precautions

Special Precautions:
Before starting trifluridine and tipiracil treatment:
• Inform your doctor and pharmacist about any allergies to trifluridine and tipiracil, other medications, or tablet ingredients. Inquire with your pharmacist for a roster of ingredients.
• Share your current prescription and non-prescription medications, vitamins, dietary supplements, and herbal products with your doctor and pharmacist.
• If you are 65 years or older or have a history of liver or kidney disease, communicate this to your doctor.
• If you are pregnant or planning pregnancy, discuss this with your doctor. During treatment, you should use effective contraception methods to prevent pregnancy. If you are a man and your partner can become pregnant, use condoms while taking this medication and for 3 months after treatment. If you or your partner becomes pregnant while you are on trifluridine and tipiracil, contact your doctor immediately.
• If you are breastfeeding, expect your doctor to advise against breastfeeding during treatment and for one day after your final dose.


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