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Dihydroergotamine mesylate, the active ingredient in Migranal Nasal Spray, acts on serotonin (5-HT) receptors in the brain to induce vasoconstriction (narrowing of blood vessels) around the brain. This action is believed to alleviate the pain of migraine headaches. It may also affect other pain pathways and inflammation related to migraine headaches.
Migranal Nasal Spray, containing the active ingredient dihydroergotamine mesylate, is a nasal spray medication specifically designed for migraine headaches. It belongs to a class of drugs known as ergot alkaloids, which work by narrowing blood vessels around the brain to relieve migraine headaches. This thorough overview offers extensive details about the product’s traits, application instructions, safety measures, potential side effects, interactions, and other crucial information.
| Usage | Indications: ● Migraine Headaches: Migranal Nasal Spray is indicated for the acute treatment of migraine headaches with or without aura. It is not intended for the prophylactic therapy of migraines or cluster headache management. Patient Guidelines Patients prescribed Migranal Nasal Spray should consider the following guidelines for effective and safe use: ● Understand the correct procedure for administering the nasal spray, including priming the spray before the first use. ● Use Migranal at the first sign of a migraine headache for the best outcomes. ● Do not exceed the recommended dosage to avoid increased risk of side effects. ● Inform your healthcare provider about all medical conditions, especially heart, blood vessels, or circulation issues. ● Report all medications you take, including over-the-counter drugs and supplements, to prevent potential interactions. Administration Details ● Formulation: Nasal spray solution. ● Dosage: The typical dosage involves an initial spray dose in each nostril, followed by additional doses as instructed by the healthcare provider, not to exceed the daily recommended maximum. Safety Precautions ● Avoid using Migranal if you have a history of heart disease, uncontrolled high blood pressure, or have recently used certain other migraine medications or ergotamine-containing medications. ● Pregnancy and Nursing: Migranal may be harmful to a fetus or a nursing baby; therefore, its use is not recommended for pregnant or breastfeeding women unless clearly necessary. Drug Interactions ● Migranal should not be used within 24 hours of ergotamine-containing drugs or other triptans used for migraine treatments due to the increased risk of severe side effects. ● Certain antidepressants, including SSRIs and SNRIs, may interact with Migranal, increasing the risk of serotonin syndrome, a potentially life-threatening condition. ● Migranal can have interactions with potent CYP3A4 inhibitors, leading to increased levels of dihydroergotamine and a heightened risk of adverse effects. |
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| Side Effects | ● Nasal discomfort or irritation Serious Side Effects ● Signs of allergic reaction, such as rash, itching, or swelling |
| Storage | ● Store Migranal Nasal Spray at room temperature, away from light and moisture, and keep it out of the reach of children. |
| Special Precautions | ● Continuous use for 10 or more days in a month may lead to medication overuse headaches—space out treatments to prevent this condition. ● Regular heart and blood pressure monitoring is recommended for patients with a history of cardiovascular diseases due to the risk of vasoconstrictive complications. |
| Overdose | ● Symptoms of overdose may include severe nausea, vomiting, numbness, tingling, bluish-colored fingers/toes, and confusion. ● Urgent medical attention is necessary in case of overdose, with supportive and symptomatic treatment provided to manage overdose symptoms. |
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