Misoprostol is classified under medications known as prostaglandin analogs. It exerts its effects by mimicking the activity of body-produced prostaglandins, which have several important functions, including protecting the stomach lining from the damaging effects of acid and inducing labor by stimulating uterine contractions. Through these mechanisms, Misoprostol offers a multifaceted approach to treating and preventing gastric ulcers, managing miscarriage, and facilitating childbirth.

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Misoprostol stands out as a potent medication with vital uses in gastroenterology and obstetrics, including the prevention of gastric ulcers and management of miscarriage or labor induction. Its pharmacological action as a prostaglandin E1 analog allows it to safeguard the stomach lining and induce uterine contractions effectively. This detailed analysis delves into Misoprostol’s medicinal profile, detailing its therapeutic advantages, administration protocols, safety precautions, potential side effects, drug interactions, and crucial information for patients and healthcare practitioners.

Additional information



● Gastric Ulcer Prevention: Primarily used in patients undergoing long-term non-steroidal anti-inflammatory drug (NSAID) therapy, which increases the risk of peptic ulcers.

● Obstetrics: Utilized for the medical management of miscarriage, labor induction, and cervical ripening before surgical procedures.

● Gynecological Procedures: Aids in preparation for intrauterine procedures by softening the cervix.

Patient Guidelines

● To maximize the therapeutic outcomes and ensure safe use of Misoprostol, patients should adhere to these guidelines:

● Strictly follow the prescribed dosage schedule, and do not make adjustments without consulting a healthcare professional.

● Familiarize yourself with the potential side effects to recognize and report any adverse reactions promptly.

● Misoprostol should be avoided by pregnant women for its indication in gastric ulcer prevention due to its potential to cause miscarriage.

● Inform your healthcare provider of all medications you are currently taking, including any herbal supplements, to avoid drug interactions.

● If experiencing any severe gastrointestinal discomfort, such as severe abdominal pain or persistent diarrhea, contact your healthcare provider immediately.

Administration Details

● Formulation: Available as oral tablets.

● Dosage: The dosage varies based on the indication. For gastric ulcer prevention, the common regimen is 200 mcg taken orally four times daily. In obstetric applications, dosage and administration depend on the specific condition being treated and the protocol followed by the healthcare institution.

Safety Precautions

● Pregnancy and Lactation: Misoprostol is contraindicated for ulcer prevention in pregnant women as it can induce labor or cause miscarriage. However, it's used under medical supervision for labor induction or management of miscarriage.
● Allergic Reactions: Monitor for any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, and seek immediate medical attention if they occur.

Drug Interactions

Misoprostol should be used cautiously with:

● Antacids: May alter Misoprostol’s effectiveness; specific timing between doses may be recommended.

● Other medications that affect the uterus: Careful coordination is necessary to prevent overstimulation of uterine contractions.

Side Effects

● Diarrhea and abdominal pain
● Nausea and indigestion
● Gas
● Serious Side Effects

Seek immediate medical attention if experiencing:

● Severe allergic reactions
● Excessive bleeding in obstetric use
● Signs of dehydration (from severe diarrhea


● Misoprostol should be stored at room temperature, away from moisture and heat. It should be kept in its original packaging to protect it from light. The medication should also be kept out of the reach of children and pets.

Special Precautions

● Professional Supervision: Given its potent effects and the spectrum of conditions it treats, Misoprostol administration often requires close monitoring by healthcare professionals, particularly in obstetric applications.

● Informed Consent: Patients should be fully informed of the risks, especially in obstetric/gynecological uses, to make well-informed decisions regarding their treatment plans.


● In case of overdose, symptoms might include severe abdominal pain, uterine hyperstimulation, or gastrointestinal distress. Overdose necessitates immediate medical intervention, where supportive and symptomatic treatment will be provided.


100 Tablets


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