Esomeprazole, the active ingredient in Nexium, works by blocking a specific enzyme in the wall of the stomach that produces acid, thereby lowering the amount of acid in the stomach. This action helps in the treatment and prevention of conditions that arise from excess stomach acid. Unlike antacids, which neutralize acid, Nexium reduces the production of acid at the source.

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Nexium, known generically as esomeprazole, is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is utilized to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Additionally, Nexium is used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid) and to prevent gastric ulcers caused by infection with Helicobacter pylori (H. pylori) or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Additional information



● Gastroesophageal Reflux Disease (GERD): For the treatment of symptomatic GERD and for the healing of erosive esophagitis.

● Risk Reduction of NSAID-Associated Gastric Ulcer: Nexium is indicated to decrease the risk of developing gastric ulcers associated with NSAID use.

● H. pylori Eradication: To reduce the risk of duodenal ulcer recurrence, Nexium may be used in combination with antibiotics for the eradication of H. pylori.

● Pathological Hypersecretory Conditions: Including Zollinger-Ellison syndrome.

Patient Guidelines

Patients prescribed Nexium should:

● Take Nexium at least one hour before meals, ideally in the morning.

● Swallow capsules whole with water; do not crush, chew, or open them.

● For patients who have difficulty swallowing, Nexium capsules can be opened, and the granules mixed with water and taken immediately.

● Be aware of potential side effects and interactions with other medications.

Administration Details

How to Use Nexium:

● Oral Administration: Nexium is most commonly taken by mouth, once a day, typically one hour before a meal.

● Dosage Forms: Available in delayed-release capsules and as an oral suspension.


● The dosage of Nexium varies based on the patient's condition, age, and response to treatment.

Safety Precautions

● Pregnancy and Lactation: The use of Nexium during pregnancy and lactation should be considered only if the potential benefits outweigh the risks.

● Long-term Use: Long-term use of Nexium, like other PPIs, may be associated with increased risks of bone fractures and deficiency of magnesium or vitamin B12.

Drug Interactions

Nexium can interact with:

● Certain antiretrovirals, anti-fungal medications, and other drugs metabolized by liver enzymes.

● Clopidogrel: Nexium can reduce the effectiveness of clopidogrel, a heart medication.

● Methotrexate: Patients taking high doses may require adjustments in their methotrexate dosage.

Side Effects

● Headache
● Diarrhea
● Nausea
● Stomach pain
● Dizziness

Serious Side Effects

Seek immediate medical attention for:

● Severe allergic reactions
● Signs of low magnesium such as dizziness, irregular heartbeat, or muscle spasms
● Symptoms of lupus-like syndrome (e.g., joint pain, rash on cheeks or arms that worsens in sunlight)


● Nexium should be stored at room temperature, away from moisture and direct light.

Special Precautions

● Bone Health: Patients on long-term Nexium therapy should be monitored for bone density and given supplements if necessary.

● Liver Function: People with severe liver problems may require adjusted dosages of Nexium.


● Symptoms of Nexium overdose can include confusion, headache, drowsiness, blurred vision, rapid heartbeat, nausea, sweating, flushing, and dry mouth. An overdose requires immediate medical attention, and treatment will be symptomatic and supportive.


20 MG, 40 MG


28 Tablets


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