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Norvasc serves as a potent vasodilator, targeting the vascular smooth muscles to promote relaxation and enhance blood flow, thereby reducing blood pressure and alleviating the strain on the heart. By preventing calcium from entering the smooth muscle cells of the heart and arteries, Norvasc effectively diminishes the onset of chest pain associated with angina and mitigates the risk of hypertension complications like stroke and heart attack.
Norvasc, a widely recognized brand name for amlodipine besylate, holds a pivotal role in the pharmacological management of hypertension (high blood pressure) and angina pectoris (chest pain). As a calcium channel blocker, Norvasc primarily works by dilating blood vessels, which helps to improve blood flow and subsequently reduce the workload on the heart.
| Usage | Indications: ● Hypertension: Effective in lowering elevated blood pressure, which, if left untreated, can lead to cardiovascular diseases, including stroke, heart attack, heart failure, and aneurysm. ● Chronic Stable Angina: Aids in managing chest pain that occurs with predictable levels of physical exertion or stress. ● Vasospastic Angina: Targeted for those experiencing chest pain at rest, often at night, caused by spasms in the arteries of the heart. Administration Guidelines ● Consume Norvasc exactly as prescribed by a healthcare provider. ● Can be taken with or without food. ● For hypertension, initial treatment does not preclude subsequent adjustments based on patient response. ● Continuous use even if symptoms of high blood pressure or angina are not present is crucial. Administration Details Dosage Forms: ● Norvasc is available in tablet form in dosages of 2.5 mg, 5 mg, and 10 mg of amlodipine besylate. Dosage: ● The usual initial antihypertensive oral dose of Norvasc is 5 mg once daily, with a maximum dose of 10 mg daily. ● Adjustments can be made according to patient response and tolerance. Safety Precautions ● Pregnancy and Lactation: Discuss potential risks and benefits with a healthcare provider if pregnant, planning to become pregnant, or breastfeeding. ● Drug Interactions: Notify your healthcare provider about all the medications you are taking to mitigate adverse interactions. ● Liver Impairment: Caution is advised in patients with severe liver impairment. Dose adjustments may be necessary. Drug Interactions Significant drug interactions may affect how Norvasc works or increase the risk of serious side effects. Notable interactions can occur with: Simvastatin: Limits the dose of simvastatin when used concomitantly with Norvasc, due to an increased risk of myopathy and rhabdomyolysis. Other antihypertensive drugs: May potentiate the blood-pressure-lowering effect and require dosage adjustments. |
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| Side Effects | ● Swelling of the ankles or feet (edema) Serious Side Effects Although rare, some may experience severe side effects such as: ● More severe dizziness or fainting |
| Storage | ● Store Norvasc at room temperature, away from light and moisture. Do not store in the bathroom, and keep all medications away from children and pets. |
| Special Precautions | ● Hypotension: Monitor for symptoms of hypotension and consult a healthcare provider for persistent issues. ● Geriatric Use: Initial dosing at the lower end is recommended for elderly patients due to a greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. |
| Overdose | ● In the case of overdose, immediate medical intervention is necessary. Signs of overdose may include severe dizziness, fainting, and an extremely slow heartbeat. |
| Mg | 5 MG, 10 MG |
| Tablets | 100 Tablets |
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