Prednisone

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Prednisone is effectively a prodrug, converted by the liver into prednisolone, the active steroid. It operates by mirroring endogenous corticosteroids’ anti-inflammatory and immunosuppressive activities, significantly reducing inflammation and moderating the immune system’s response. This action makes it invaluable in treating conditions ranging from chronic autoimmune diseases like systemic lupus erythematosus and rheumatoid arthritis to acute conditions including, but not limited to, asthma flare-ups and severe allergic reactions.

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Description

Prednisone is a synthetic glucocorticoid, a class of corticosteroids known for their potent anti-inflammatory and immune-modulating effects. Widely utilized across various medical disciplines—including but not limited to endocrinology, dermatology, rheumatology, and pulmonology—prednisone has become a staple in treating a diverse array of inflammatory, autoimmune, and allergic disorders. It is commonly available in tablet form and as an oral solution, offering versatility in dosing for different patient needs.

Additional information

Usage:	Indications: ●Autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel diseases. ●Respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD). ●Severe allergic outbreaks that require intervention beyond antihistamines. ●Prevention of organ transplant rejection. ●Certain hematological and neoplastic diseases including lymphoma and leukemia. ●As part of palliative care in specific terminal conditions to improve quality of life. Administration Guidelines ●Oral Administration: Prednisone tablets or oral solutions are usually taken with food or milk to mitigate gastrointestinal side effects. Dosages are highly patient-specific, tailored to the severity of the condition, the patient's response to the therapy, and the duration for which treatment is deemed necessary. Dosage Forms: ●Prednisone is primarily administered orally as tablets or a liquid solution, simplifying dose adjustments and administration. Dosage: ●The prednisone dosing regimen is highly individualized, and tailored to the specifics of the patient's condition. Based on the treatment objective and patient response, initial doses can range broadly from 5 mg to higher doses of 60 mg or more daily. Safety Precautions ●Pregnancy and Breastfeeding: The utilization of prednisone during pregnancy and breastfeeding carries potential risks, necessitating a careful balance between therapeutic benefits and possible adverse effects. ●Prolonged Use: Chronic administration of prednisone may lead to serious side effects, including osteoporosis, increased susceptibility to infections, weight gain, skin changes, and alterations in mood or behavior. ●Infections: Given its immunosuppressive capability, prednisone can heighten the risk for developing new infections or exacerbate existing ones. Drug Interactions ●Prednisone interacts with numerous drugs, which may lead to decreased effectiveness of medications or amplify their side effects. It's crucial to inform healthcare providers about all medicines when starting prednisone.
Side Effects:	●Increased appetite and weight gain. ●Difficulty sleeping, mood swings. ●Stomach discomfort, potential for ulcers. ●Altered blood sugar levels, impacting diabetes management. Serious Side Effects More severe risks include, but are not limited to: ●Hypertension and elevated risk of thrombosis. ●Gastrointestinal bleeding linked to peptic ulcer disease. ●Enhanced vulnerability to current or emerging infections. ●Long-term bone demineralization and muscle weakness. ●Suppression of the adrenal gland, risking adrenal crisis if treatment is stopped abruptly.
Storage:	●Prednisone should be stored securely at room temperature, shielded from light and moisture, and kept out of reach of children. Oral liquid forms must be closed tightly and stored per the label's instructions to maintain stability and prevent contamination.
Special Precaution	●Regular medical supervision is essential for patients on long-term prednisone therapy. This includes monitoring for adverse effects on bone density, blood pressure, glucose levels, and mental health.
Overdose	●Symptoms of prednisone overdose may include but are not limited to fluid retention, elevated blood pressure, and hyperglycemia. An overdose constitutes a medical emergency requiring immediate intervention. For the oral liquid form, while overdose is less dangerous, consultation with healthcare professionals for appropriate measures is advised.
MG	5 MG, 50 MG
Tablets	100 Tablets