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Saphris acts on various neurotransmitter receptors in the brain, exhibiting a high affinity for serotonin and dopamine receptors. This multimodal action helps in stabilizing mood and reducing the symptoms of psychosis and mania. Its sublingual form avoids first-pass metabolism, making the medication more bioavailable and leading to prompt therapeutic effects.
Saphris is an atypical antipsychotic medication containing the active ingredient asenapine, used primarily in the treatment of schizophrenia and bipolar I disorder. It improves thinking, mood, and behavior by rebalancing dopamine and serotonin. Saphris’s unique sublingual administration (placed under the tongue) ensures rapid absorption and effectiveness in managing psychiatric symptoms.
| Usage | Indications: ● Treatment and management of schizophrenia. Administration Guidelines: ● Sublingual Administration: Saphris tablets are to be placed under the tongue and allowed to dissolve completely, enhancing the drug's bioavailability. ● Patients are advised not to eat or drink for 10 minutes after taking Saphris to ensure optimal absorption. Dosage Forms: ● Saphris is available in sublingual tablets, typically in 5 mg and 10 mg dosages. Safety Preclusions Pregnancy and Breastfeeding: ● Caution is advised when prescribing Saphris to pregnant or breastfeeding mothers, considering the potential risks and benefits, as its safety in these populations is not definitively established. Long-term Use: ● Regular monitoring by healthcare providers is essential during long-term use of Saphris, focusing on managing any side effects and assessing the ongoing effectiveness of the medication. Drug Interactions: ● Saphris can interact with several medications, including CNS depressants and drugs known to affect the serotoninergic neurotransmitter systems. Patients should provide a full medication history to avoid adverse interactions. |
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| Side Effects | ● Common side effects include dizziness, increased appetite, and weight gain. Serious Side Effects: ● Potential metabolic changes include increased blood sugar, cholesterol, and weight. |
| Storage | ● Store the sublingual tablets at room temperature in their original package. |
| Special Precautions | Patients and caregivers should be aware of the importance of adhering to the prescribed treatment regimen and be informed about potential side effects, including signs of metabolic changes and tardive dyskinesia. Regular psychiatric assessments and physical check-ups are necessary to monitor the patient’s response to treatment and adjust the therapy as needed. |
| Overdose | Symptoms of a Saphris overdose may range from sedation, and confusion, to more severe conditions such as hypotension or respiratory depression. Immediate medical attention is necessary in the event of an overdose, with supportive care being the mainstay of treatment. |
| MG | 5 MG, 10 MG |
| Tablets | 60 Tablets |
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