Doxepin is available in capsule, tablet, and oral concentrate form and is designed for oral administration. The mechanism of doxepin primarily involves balancing the neurotransmitters in the brain, contributing to its antidepressant, anxiolytic, and hypnotic effects. By increasing the levels of serotonin and norepinephrine, doxepin helps in improving mood and providing relief from anxiety and insomnia.

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Doxepin, marketed under the brand name Sinequan among others, is an oral medication belonging to the tricyclic antidepressant (TCA) class of drugs. It is used for the treatment of major depressive disorder, anxiety disorders, chronic hives, and trouble sleeping. Doxepin works by inhibiting the reuptake of neurotransmitters serotonin and norepinephrine in the brain, thus altering mood and reducing symptoms of depression and anxiety.

Additional information



● Treatment of major depressive disorder (MDD) in adults.

● Management of anxiety disorders, offering relief from the symptoms.

● Treatment of insomnia, specifically in patients who require a sedative component for their sleep disturbances.

● Management of chronic idiopathic urticaria (hives), providing relief from itching and rash.

Administration Guidelines:

● Doxepin can be taken with or without food. Capsules or tablets should be ingested whole with water.

● Oral concentrate must be mixed with water or milk before ingestion.

● Dosages are tailored based on the specific condition being treated, the patient's age, and the response to therapy. It's critical to adhere to the prescribing healthcare provider's instructions.

● Like many antidepressants, doxepin may start at a low dose to minimize the risk of side effects, then gradually increase as needed.

● For effective symptom control, doxepin should be taken at the same time each day.

Dosage Forms:

● Capsules: Available in doses of 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg.
● Tablets: Typically in lower doses for the treatment of insomnia.
● Oral Concentrate: Doxepin oral solution for precise dosing.

Safety Preclusions

Pregnancy and Breastfeeding:

● The use of doxepin during pregnancy or breastfeeding should be discussed with a healthcare provider. It may not be recommended due to potential risks to the fetus or infant.

Long-term Use:

● Chronic conditions may require long-term treatment, although patients should be regularly evaluated for continued efficacy and side effects.

Drug Interactions:

● Caution is advised when doxepin is used with other medications that can affect serotonin levels, as well as certain anticholinergic drugs, and alcohol.

Side Effects

● Common side effects include dry mouth, drowsiness, dizziness, blurred vision, weight gain, constipation, and urinary retention.

Serious Side Effects:

● Risk of increased suicidal thoughts and actions, particularly in children and young adults.
● Possibility of worsening depression or anxiety.
● Severe allergic reactions.


● Capsules and tablets should be stored at room temperature, away from moisture and direct light.

● Oral concentrate should be stored according to the product's instructions, usually in a cool, dry place, and any unused portion discarded after a certain period.

Special Precautions

● Gradual tapering of the dose is recommended when discontinuing doxepin to avoid withdrawal symptoms.

● Patients should be monitored for suicidal ideation, particularly at the beginning of treatment or when doses are adjusted.


● Symptoms of an overdose may include extreme drowsiness, confusion, hallucinations, convulsions, or coma. An overdose of doxepin is a medical emergency and requires immediate attention from healthcare professionals. Management includes symptomatic and supportive measures.


10 MG, 25 MG, 75 MG, 100 MG


100 Capsules


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