Tasigna (Nilotinib Hydrochloride Monohydrate)

$4,471.19$5,917.19

Nilotinib is prescribed to manage specific forms of chronic myeloid leukemia (CML), a type of white blood cell cancer. It is utilized for individuals whose CML hasn’t responded well to imatinib (Gleevec) or for those who cannot tolerate imatinib treatment. This medication belongs to the kinase inhibitor class and functions by inhibiting the activity of an abnormal protein that triggers the multiplication of cancer cells. This action serves to halt or impede the proliferation of cancerous cells.

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Description

Nilotinib is prescribed to manage specific forms of chronic myeloid leukemia (CML), a type of white blood cell cancer. It is utilized for individuals whose CML hasn’t responded well to imatinib (Gleevec) or for those who cannot tolerate imatinib treatment. This medication belongs to the kinase inhibitor class and functions by inhibiting the activity of an abnormal protein that triggers the multiplication of cancer cells. This action serves to halt or impede the proliferation of cancerous cells.

Additional information

Usage

Usage
Nilotinib is administered in capsule form, to be taken orally. Typically, it is taken twice a day on an empty stomach, with doses spaced approximately 12 hours apart. Nilotinib should be ingested at least 1 hour before or 2 hours after eating any food. It's important to follow your prescription label's instructions meticulously and don't hesitate to consult your doctor or pharmacist if there's anything you don't understand. Take nilotinib precisely as prescribed—do not exceed or reduce your dose or take it more frequently than directed by your physician. Swallow the capsules whole with a glass of water, avoiding splitting, chewing, or crushing them. In cases where swallowing whole capsules is not possible, you may mix the contents of a capsule with one teaspoon of applesauce and consume the mixture immediately (within 15 minutes). Avoid keeping the mixture for later use. Your doctor may adjust your nilotinib dose throughout your treatment, depending on its efficacy and any encountered side effects. Continue taking nilotinib even if you feel well, and do not discontinue it without consulting your doctor.

Side Effects

Side Effects
Nilotinib may lead to side effects. Inform your doctor if any of the following symptoms become severe or persist:
• Rash
• Itching
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Heartburn
• Gas
• Loss of appetite
• Headache
• Dizziness
• Fatigue
• Difficulty sleeping or staying asleep
• Night sweats
• Muscle cramps
• Pain in the back, bones, joints, limbs, or muscles
• Hair loss
• Dry or reddened skin
Some side effects can be serious. Contact your doctor immediately if you experience any of these symptoms or those listed in the IMPORTANT WARNING section:
• Unusual bleeding or bruising
• Blood in the urine
• Bloody or black, tarry stools
• Unusual fatigue or weakness
• Fever, chills, sore throat, ongoing cough, congestion, or signs of infection
• Shortness of breath
• Swelling of the hands, ankles, feet, or face
• Sudden abdominal pain
• Yellowing of the skin and eyes
Nilotinib may also cause other side effects. Reach out to your doctor if you encounter any unusual issues while taking this medication.

Storage

Storage
To ensure medication safety:
• Keep it in the original container, sealed, and away from children.
• Store at room temperature, avoiding moisture and excessive heat.
• Dispose of unneeded medication safely via take-back programs or ask your pharmacist.
• Never flush medication down the toilet.
• Safeguard medication from children, as some containers are not child-resistant.
• Use safety caps and store them out of children's reach.

Precaution

Before taking nilotinib:
• Inform your doctor and pharmacist of any allergies to nilotinib or other medications.
• Disclose all prescription, and nonprescription medications, vitamins, and supplements you're taking.
• Mention any heart issues, pancreatitis, stomach removal surgery, or difficulty digesting sugars.
• Discuss pregnancy plans, and use contraception during treatment; if pregnant, contact your doctor immediately.
• Avoid breastfeeding while on nilotinib.
• Inform healthcare providers about nilotinib usage before undergoing surgery or dental procedures.

Warning

Important Warning
Nilotinib may lead to QT prolongation, causing irregular heart rhythms and severe outcomes. Notify your doctor of long QT syndrome in your family, low blood levels of potassium or magnesium, irregular heartbeat, or liver disease. Disclose the use of specific medications that may interact with nilotinib. If you experience rapid, irregular heartbeat, fainting, or seizures, cease nilotinib and contact your doctor immediately. Take nilotinib on an empty stomach, and adhere to scheduled appointments for tests, including EKGs. Discuss potential risks with your doctor.

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