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Tizanidine is a medication marketed under the brand name Zanaflex, among others. It is used primarily for managing and treating muscle spasticity, a condition in which muscles continually contract, leading to stiffness and pain. Tizanidine functions as a short-acting muscle relaxer, working centrally (in the brain) to block nerve impulses sent to the brain.
Tizanidine is a medication marketed under the brand name Zanaflex, among others. It is used primarily for managing and treating muscle spasticity, a condition in which muscles continually contract, leading to stiffness and pain. Tizanidine functions as a short-acting muscle relaxer, working centrally (in the brain) to block nerve impulses sent to the brain.
| Usage | Indications: ● Muscle Spasticity: Known for its effectiveness in reducing clonus, and muscle rigidity, aiding in managing spasticity symptoms due to conditions like multiple sclerosis and spinal cord injury. Administration Guidelines Dosage: ● The dosage of Tizanidine is tailored to the individual's needs. Usually, therapy starts with a dose of 2 mg. Due to the potential for side effects, any dosage increase should be gradual. Administration frequency can range from one dose daily to up to four doses per day, depending on the severity of symptoms and patient response. Method of Administration: ● Tizanidine tablets should be taken orally, with or without food. However, consistency in taking this medication concerning meals is advisable to maintain the same drug effect and absorption rate daily. Dosage Form: ● Oral tablets. Safety Preclusions Pregnancy and Breastfeeding: ● The safety of Tizanidine in pregnancy and breastfeeding is not established. It should be used only when the potential benefits justify the possible risk to the fetus. It's unknown if Tizanidine is excreted in human milk. Caution is advised. Drug Interactions: ● Tizanidine should be used cautiously with medications such as blood pressure medications, CYP1A2 inhibitors like some antiarrhythmics, and fluoroquinolone antibiotics, as it may lead to significant interaction effects. |
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| Side Effects | Indications: ● Muscle Spasticity: Known for its effectiveness in reducing clonus, and muscle rigidity, aiding in managing spasticity symptoms due to conditions like multiple sclerosis and spinal cord injury. Administration Guidelines Dosage: ● The dosage of Tizanidine is tailored to the individual's needs. Usually, therapy starts with a dose of 2 mg. Due to the potential for side effects, any dosage increase should be gradual. Administration frequency can range from one dose daily to up to four doses per day, depending on the severity of symptoms and patient response. Method of Administration: ● Tizanidine tablets should be taken orally, with or without food. However, consistency in taking this medication concerning meals is advisable to maintain the same drug effect and absorption rate daily. Dosage Form: ● Oral tablets. Safety Preclusions Pregnancy and Breastfeeding: ● The safety of Tizanidine in pregnancy and breastfeeding is not established. It should be used only when the potential benefits justify the possible risk to the fetus. It's unknown if Tizanidine is excreted in human milk. Caution is advised. Drug Interactions: ● Tizanidine should be used cautiously with medications such as blood pressure medications, CYP1A2 inhibitors like some antiarrhythmics, and fluoroquinolone antibiotics, as it may lead to significant interaction effects. |
| Storage | ● Store Tizanidine at room temperature, away from moisture and heat. ● Keep the medication safely out of reach of children. |
| Special Precautions | ● Patients with liver problems should use Tizanidine with caution, as this drug can significantly increase liver enzymes. Regular liver function tests might be recommended to monitor for potential liver damage. |
| Overdose | ● Symptoms of overdose may include confusion, slow heart rate, dizziness, shallow breathing, and even unconsciousness. Emergency medical attention should be sought if an overdose is suspected. |
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