Atacand Plus


Atacand Plus is a combination prescription medication used primarily for the treatment of hypertension (high blood pressure). This medication combines two active ingredients: candesartan cilexetil, which is an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic (water pill). Candesartan relaxes blood vessels, while hydrochlorothiazide helps eliminate excess salt and water from the body. These two components’ synergistic effects help lower blood pressure more effectively than either component alone.

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Due to its dual ingredients, Atacand Plus addresses hypertension through two mechanisms. Candesartan cilexetil targets the angiotensin II receptor, preventing vasoconstriction and reducing the blood volume the heart needs to pump, thus lowering blood pressure. Hydrochlorothiazide aids in reducing blood volume by promoting the excretion of sodium and water in the urine. Combining an ARB with a diuretic often achieves greater blood pressure reductions than monotherapy, offering an advantage in patients who require additional control of their hypertension.

Additional information


Prescribed by a doctor, Atacand Plus is generally taken once daily, with the dosage individualized according to the patient's blood pressure response, other medical conditions, and ongoing medications. It can be taken with or without food. Therapy is typically initiated with caution, and frequent monitoring of blood pressure and kidney function is advised due to the diuretic component of the medication.

Side Effects

● Dizziness or lightheadedness from lowered blood pressure ● Dehydration or electrolyte imbalance due to the diuretic effect ● Muscle cramps or weakness ● Nausea Severe but less common side effects might involve: ● Allergic reactions with symptoms such as swelling of the face or throat ● Significant changes in kidney function or kidney failure ● Pronounced hypotension (especially in volume-depleted individuals) ● Elevated potassium levels which may affect cardiac rhythm


Atacand Plus should be stored at room temperature, out of the reach of direct sunlight and moisture. The medication should be kept in its original container, tightly closed, and out of reach of children and pets. As with all medications, it should be stored as per the instructions found on the packaging or given by the pharmacy.

Special Precautions

Before starting Atacand Plus, patients should inform their healthcare provider of their complete medical history, emphasizing any occurrences of kidney or liver disease, gout, lupus, diabetes, or asthma. They should also mention all other medications and supplements they are taking. Dehydration should be avoided, and patients may need to be cautious with the intake of potassium salt substitutes. Caution is also advised in activities requiring alertness, such as driving. Use in pregnant women, especially in the second and third trimesters, is contraindicated due to potential harm to the fetus. Nursing mothers should discuss with their doctor as Atacand Plus may pass into breast milk.


Symptomatically, overdose with Atacand Plus may cause excessive electrolyte depletion and dehydration, volume depletion, hypotension, or electrolyte disturbances. In the case of suspected overdose, supportive treatment should be initiated in a hospital setting, with monitoring and correction of vital blood parameters, kidney function, and electrolyte balance.


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