Divalproex sodium is a versatile medication designed to address a range of neurological conditions. By modifying the electrical activity in the brain and increasing the availability of certain neurotransmitters, it effectively helps control the symptoms of epilepsy, bipolar disorder, and migraines. It’s important to note that while divalproex can significantly improve these conditions, it is not considered a cure but rather a means to manage symptoms and improve the quality of life for those affected.

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Divalproex sodium, sold under brand names such as Depakote, is a medication commonly used to treat various types of seizure disorders, bipolar disorder, and migraine headaches. It is a derivative of valproic acid, which functions as an anti-convulsant and mood-stabilizing drug. Divalproex sodium works by restoring the balance of certain neurotransmitters in the brain, which helps to reduce seizures, stabilize mood, and prevent migraine attacks. The medication is available in several forms, including delayed-release and extended-release tablets.

Additional information


Indications: Divalproex is indicated for:

● Management of seizure disorders.
● Treatment of manic episodes associated with bipolar disorder.
● Prophylaxis of migraine headaches.

Patients are advised to:

● Take divalproex exactly as prescribed by their healthcare provider.
● Continue taking the medication, even if symptoms improve, to prevent relapse or worsening of their condition.
● Regularly consult with their healthcare provider to monitor their condition and adjust the dosage as needed.

Side Effects

● Nausea
● Drowsiness
● Dizziness
● Hair loss
● Weight changes

Serious side effects that require immediate medical attention include:

● Signs of liver problems (such as persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes or skin, dark urine)
● Symptoms of pancreatitis (such as severe stomach/abdominal pain, nausea, vomiting)
● Changes in mental status (confusion, difficulty concentrating)
● Severe mood or behavior changes (such as new or worsening depression, thoughts of suicide)


Divalproex should be stored at room temperature, away from light and moisture. Keep the medication in its original container, tightly closed, and out of reach of children and pets.

Special Precautions

Patients should inform their healthcare provider if they have:

● Liver problems.
● A history of pancreatitis.
● A urea cycle disorder.
● A history of depression, mood disorders, or suicidal thoughts or actions.
● If they are pregnant, planning to become pregnant, or breastfeeding.

Divalproex presents significant risks during pregnancy, including congenital malformations. It is crucial to discuss the benefits and risks of taking divalproex with a healthcare provider if pregnancy is planned or occurs. The use of effective contraception is recommended for women of childbearing age taking divalproex. It's unknown if divalproex passes into breast milk, so nursing mothers need to consult their healthcare provider.


Symptoms of divalproex overdose can include unresponsiveness, shallow breathing, fainting, or heart abnormalities. In the event of an overdose, immediate medical attention is necessary to manage these potentially life-threatening complications.


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