How Does the Body React to Lantus Insulin? | Better You Rx

How Does the Body React to Lantus Insulin?

What is Lantus Insulin?

Insulin glargine is the active component of the long-acting injectable known as Lantus. Insulin glargine is a recombinant analogue of human insulin with hypoglycemic effects that is intended to be given subcutaneously. The amino acid asparagine is absent at position A21 in insulin glargine, which is derived from the non-pathogenic strain of Escherichia coli. Instead, it has arginine at the C-terminus of both the B-chain and glycine at position A21. Although this may sound complex, it simply means that this insulin keeps your blood sugar levels under control by working for extended periods of time.

How does the body react to Lantus insulin?

Lantus Insulin: How Does It Operate? Lantus is a medication that efficiently lowers increased blood sugar levels for better glycemic control. It is indicated for adult patients with type I and type II diabetes as well as pediatric patients with type I diabetes. It works to reduce blood sugar levels by metabolizing glucose. This medicine increases peripheral glucose absorption, especially by fat and skeletal muscle, while inhibiting glucose production in the liver. Lantus is thought to stop proteolysis and lipolysis, promoting protein synthesis. Through the intake of amino acids by the hepatic and muscular tissues, the injection also encourages DNA replication. Additionally, this insulin medication aids in promoting glycogenesis, which opposes catabolism and helps to enhance energy storage.

Insulin glargine is necessary for growth, participates in the regulation of growth hormones, and affects cell division. Lantus is essentially insoluble at a neutral pH, whilst it is entirely soluble at an acidic pH   (pH 4). The solution goes through neutralization after administration and loses its acidity. As a result, microprecipitates are created, wherein insulin glargine is slowly released in minute amounts. This helps to provide a constant concentration/time pattern without any obvious peaks, enabling once-daily dosing. The risk of nocturnal hypoglycemia is also decreased. The medication can imitate the basal levels of insulin because to its typical action profile, aiding in the day-long maintenance of glycemic control.

How does the body benefit from Lantus Insulin?

A long-acting insulin analog called Lantus insulin is used to treat diabetes mellitus. The body gains from it in a number of ways:

  1. Blood sugar control: Lantus assists diabetics in controlling their blood sugar levels. By reducing blood glucose levels, it enables cells to efficiently receive and utilize glucose as an energy source.
  2. Long-lasting duration of action: Lantus is referred to as a background or basal insulin since it exerts its effects over a considerable amount of time (about 24 hours). As a result, a consistent supply of insulin is available throughout the day, assisting in the maintenance of stable blood sugar levels between meals and throughout periods of fasting.
  3. Reduces hyperglycemia: Lantus lowers hyperglycemia (high blood sugar) by regulating blood sugar levels. Over time, having high blood sugar can cause a number of concerns, including heart disease, nerve damage, renal problems, and eye problems.
  4. Supports effective carbohydrate metabolism: Lantus aids the body in properly metabolizing carbs. It makes it possible for glucose to enter cells, where it can either be used to create energy or stored as glycogen in the muscles and liver.
  5. Prevents ketoacidosis: Inadequate insulin levels can cause the body to break down fat for energy, which produces ketones. Diabetic ketoacidosis (DKA), a dangerous disease, can result from high ketones. Lantus assists in preventing DKA by keeping insulin levels steady.
  6. Enhances general wellbeing: People with diabetes can live better overall when their blood sugar levels are properly controlled with Lantus insulin. High blood sugar symptoms like increased thirst, frequent urination, lethargy, and blurred vision are lessened by it.


The advantages of Lantus insulin should only be used as directed by a healthcare provider and in conjunction with a thorough diabetes management strategy that includes diet, exercise, and routine blood sugar monitoring. It’s crucial to speak with a healthcare professional if you have diabetes or believe you might have it in order to find out the best course of action for your individual requirements.

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