Hydrochlorothiazide operates by inhibiting the kidneys’ ability to retain sodium, thereby increasing urine production. This not only helps to remove excess fluid from the body but also aids in relaxing the blood vessel walls. The combined effect significantly reduces blood pressure and the workload on the cardiovascular system.

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Hydrochlorothiazide, widely recognized under the brand name Microzide among others, is a medication commonly prescribed to manage high blood pressure (hypertension) and fluid retention (edema). It belongs to a class of drugs called thiazide diuretics, often referred to as water pills. Hydrochlorothiazide helps reduce fluid retention and lower blood pressure by increasing the amount of urine produced, preventing strokes, heart attacks, and kidney problems.

Additional information


Hydrochlorothiazide is indicated for:

● The treatment and management of hypertension.
● The reduction of edema associated with heart failure, cirrhosis of the liver, chronic kidney failure, corticosteroid medications, and estrogen therapy.
● Sometimes used in treating nephrogenic diabetes insipidus and to prevent kidney stones in patients with high calcium levels in their urine.

Patients are advised to:

● Consume hydrochlorothiazide early to avoid sleep disturbances due to increased urination.
● Follow the dosage instructions their healthcare provider provides to ensure effectiveness while minimizing potential side effects.


● Hydrochlorothiazide may cause an imbalance in electrolytes (e.g., potassium, sodium, magnesium) and should be monitored regularly.
● It may increase sensitivity to sunlight, warranting the use of sunscreen and protective clothing.
● Usage can lead to dehydration and decreased blood volume, cautioning against excessive use

Side Effects

Common side effects may include:

● Dizziness or lightheadedness
● Dehydration symptoms, such as thirst and dry mouth
● Weakness
● Nausea

Serious side effects that require medical attention can entail:

● Eye pain or vision problems, which could indicate a rare increase in pressure inside the eye (acute narrow-angle glaucoma)
● Severe electrolyte imbalance
● Signs of allergic reactions, such as rash, itching, swelling, severe dizziness, and trouble breathing


● Store hydrochlorothiazide at room temperature between 68°F to 77°F (20°C to 25°C).
● Keep the medication away from light, moisture, and children and pets out of reach.

Special Precautions

Before initiating treatment, it's crucial to communicate with your healthcare provider if:

● You have allergies, diabetes, gout, kidney disease, liver disease, lupus, or minimal urination capability.
● Due to potential interactions, you are taking other medications or supplements, especially other blood pressure medications, lithium, or digoxin.
● You are pregnant, planning to become pregnant, or breastfeeding, considering the medication's effects on your baby.


Symptoms of hydrochlorothiazide overdose include severe dehydration, electrolyte imbalance (particularly low potassium and sodium levels), weakness, and fainting. In the event of a suspected overdose, immediate medical intervention is necessary. Contact emergency services or head to the nearest emergency room, providing them with details about the overdose timing and quantity.


100 Tablets


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